Study of platelet parameters in bacterial infections of lower respiratory tract
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2018, Vol 4, Issue 4
Abstract
Background: Respiratory tract infections are one of the commonest bacterial infections. Platelets play an important role in inflammatory response against infectious agents. Bacterial components activate platelets to release inflammatory mediators. The changes platelets undergo during their activation are reflected in the platelet parameters. This study aims to evaluate platelet parameters in the lower respiratory tract infections. Materials & methods: Cross-sectional study on sputum culture proven bacterial infections of the lower respiratory tract was done for three months. Platelet parameters of 94 cases were compared with 94 healthy controls. Cases were sub grouped as group A (with leucocytosis) and group B (without leukocytosis). Comparative analysis of platelet parameters between these subgroups and controls was done. P value was calculated and <0.05 was considered significant. Results: Platelet count (p <0.05) and plateletcrit were higher, Mean platelet volume (p <0.05), Platelet distribution width (p <0.001) and Platelet large cell ratio were lower in cases compared to controls. Group A showed significantly higher PLT (p < 0.05) and PCT (p <0.001) than group B whereas the difference in other parameters was not significant. All platelet parameters were significantly altered in patients with leukocytosis on comparison with controls whereas only MPV, PDW and P-LCR showed significant change in patients without leukocytosis when compared with controls. Conclusion: Platelet parameters show variation in the lower respiratory tract infections. As they can be determined as a part of routine complete blood picture analysis, they may be considered as markers of inflammation in the diagnosis of lower respiratory tract infections.
Authors and Affiliations
B Lakshmi Durga Srujana, Sushma Yalavarthi, Vasudha C. L
Keywords
Related Articles
- EP ID EP376465
- DOI 10.17511/ jopm. 2018.i4.02
- Views 149
- Downloads 0
Cutaneous metastasis: Indicators of internal malignancy diagnosed on fine needle aspiration cytology
Introduction: Cutaneous metastases (CM) from various malignancies are uncommon with incidence of 0.8-4% and indicate disseminated disease with poor outcome. Metastatic adenocarcinoma to the skin occurs from gastro-intest...
Histopathological overview of cystoscopic bladder biopsies- A retrospective analysis
Background: Wide spectrums of nonneoplastic and neoplastic lesions are observed in urinary bladder. Correlation between clinical findings and histopathological features is essential in arriving at a correct diagnosis. Th...
Bacteriology of infected burn wounds in hospitals in and around Davangere
Introduction: Study was conducted to isolate and identify the aerobic bacterial flora in burn wound patients admitted in and around hospitals of Davanagere. It also includes knowing common microbial pathogen involved in...
A study of leukemias Profile in central India
Introduction: Leukemia was considered as a rare disease few years back. However, it is increasing in incidence and prevalence slowly and steadily. Leukemias are euplastic proliferations of haematopoietic cells and form a...
Clinico-histopathological analysis of malignant soft tissue tumors
Background: Aim of the study was to analyze the histopathological findings in various malignant soft tissue tumors and to study its incidence in relation to age, gender and anatomical site. Material and Method: Total of...