Study of prescription pattern in the management of herpes zoster at brims hospital, bidar
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 1
Abstract
Aim & Objectives 1. To study the prescription patterns in Herpes Zoster cases in BRIMS Tertiary Hospital. 2. To assess the efficacy, tolerability and adverse drug reactions of the drugs used in treatment of Herpes Zoster. Materials and Methods This was a prospective study conducted on both outpatients and inpatients of BRIMS Tertiary Hospital, Bidar, from 11-8-2014 to 12-08-2015 on patients with herpes zoster attending Department of Dermatology. A total of 90 patients with herpes zoster who presented within 72 hours of the onset of rash were enrolled in the study and randomized into three groups of 30 each of whom 30 patients assigned Valacyclovir 1000 mg TID, 30 patients were assigned Acyclovir 800 mg five times a day and Famciclovir 250 mg BD for 7 days. The treatments were given for 7 days. Patients were periodically followed up till day 29 to assess the effect of the drugs on the rate of resolution of pain, cessation of abnormal sensations, rate of rash healing, new lesion formation and occurrence of complications. Results The pain scores (measured by VAS) between the groups were compared and a significant reduction was observed in Valacyclovir group day 22 (P=0.013) and day 29 (P<0.0004). A significantly greater proportion of patients in Valacyclovir group did not have Zoster associated pain at day 29 (P=0.003). All the three drugs showed significant reduction in pain scores within the group between 2 consecutive visits. This trend was persistent throughout the study period. The rate of cessation of abnormal sensations, rash healing, new lesions formation and occurrence of complications was similar in three groups. Adverse events were infrequent and mild in nature. Headache, nausea, vomiting and abnormal pain were reported which did not warrant discontinuation and withdrawal from the study. Conclusion In the management of HerpesZoster the reduction of pain was best with Valacyclovir better with Famciclovir and least in Acyclovir. Other than resolution of pain which is faster with Valacyclovir than compared to Acyclovir and Famciclovir, there is no difference in outcome of rash healing, abnormal sensation and adverse effect with three drugs.
Authors and Affiliations
Savitha A
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