Study of prevalence of multidrug resistant (MDR) Enterococci at a tertiary care hospital of Rajasthan
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 7
Abstract
Background: Enterococci, though commensals in adult faeces are important nosocomial pathogens. Their emergence in past two decades is in many respects attributable to their resistance to many commonly used antimicrobial agents (aminoglycosides, cephalosporins, aztreonam, semisynthetic penicillin, trimethoprim-sulphamethoxazole). Objectives: To study the prevalence of Multidrug resistant (MDR) Enterococci plus Vancomycin resistance and High Level Gentamicin Resistance (HLGR) in different enterococcal isolates. Materials and methods: Total 125 enterococcal isolates were studied. Identification was done by conventional biochemical methods. Antibiotic susceptibility testing was done by Kirby-Bauer disc diffusion method on Mueller–Hinton agar and results were interpreted as per CLSI guidelines. Enterococci resistant to more than three drugs plus high level Gentamicin (120 µg) resistance were labelled as multidrug resistant (MDR). HLGR was determined by disc diffusion method using high level Gentamicin disc (120 µg). Minimum inhibitory concentration (MIC) determination for detecting Vancomycin resistance was done by HiComb MIC Test strips and microbroth dilution method. Results: Total 125 entetococcal isolates were studied. In this study the multiple drug resistance was verified in 44 (35.20%) isolates of Enterococcus species and only 2 isolates (1.72%) were found to be VRE but HLGR was detected in 53.6% of the isolates. Conclusion: During past two decades, enterococci resistant to multiple antimicrobial agents have been recognized, including strains resistant to vancomycin, β-lactams and aminoglycosides, making it a formidable nosocomial pathogen. Such strains pose therapeutic dilemmas for clinicians. Thus, it is crucial for laboratories to provide accurate antimicrobial resistance patterns for enterococci so that effective therapy and infection control measures can be initiated.
Authors and Affiliations
Surbhi Mathur
Keywords
Related Articles
- EP ID EP429268
- DOI -
- Views 99
- Downloads 0
The diagnostic efficiency of sigmoidoscopy in patients with bleeding per rectum
Background: Rectal bleeding is the most common symptom of large bowel pathology which comprises 14 to 19% in adult population. Sigmoidoscopy is a feasible and safe method for diagnosing colorectal problems than colonosco...
Acute pancreatitis: Causes, pathophysiology, different modalities of management
Background: This study was intended to throw light upon the topic of acute pancreatitis, its incidence, etiology, pathogenesis as well as its management. Aim and objectives: To review and study the patients who presente...
Perceptions of patients’ towards euthanasia – A medico-legal perspective
Background: Euthanasia is a matter of debate since its origin and till now. Few countries have proper legislation for the same while in India, the matter is always remain unnoticed. Present study was aimed to analyze per...
A prospective study evaluating the effectiveness of epidural volume extension with normal saline in combined spinal epidural anesthesia for lower limb orthopedic surgeries using low dose intrathecal hyperbaric bupivacaine
Background: Combined spinal-epidural anesthesia technique for providing pain relief for orthopedic procedures has gained popularity. It combines the advantages of rapid onset and the reliability of blockade obtained spin...
A study of assessing cardiotoxicity by MUGA technique in patients treated for carcinoma breast
Introduction: Adriamycin is one of the commonly used chemotherapeutic drugs in breast cancer which induce cardiotoxicity ranges from benign arrhythmias to potentially lethal cardiomyopathy. Aim: To study on assessing adr...