Study of qualitative and quantitative composition of lipophilic compounds in the extract of pumpkin pulp (Cucurbita pepo L.)
Journal Title: Фармацевтичний журнал - Year 2014, Vol 4, Issue 4
Abstract
The extracts of medicinal plants included into the composition of many drugs as active substances. Due to the presence in plants of different classes of biologically active substances with different pharmacological effects, it is possible to usethem for the treatment and prevention of many diseases. One of such plantsis pumpkin (Cucurbita pepo L.), which belongs to the family Cucurbitaceae. The aim of our work was investigation and studying at the chemical composition of biologically active compounds of the lipophilic extracts of pumpkin by the method of chromatography-mass spectrometry. The object of the study was lipophilic extract of pumpkin pulp meal which had been prepared by using the hexane as solvent (1:6). The cake of pumpkin pulp from the (Cucurbita pepo L. and Cucurbita moschata (Duch) Poir.) after juice production in 2013 was the raw material for producing at the extract. In the lipophilic extract of pumpkin pulp 37 compounds. Of the seare present 10 fattyacids, of which 7 – saturated (lauric, caproic, myristic, palmitic, pentadecanoic, heptadecanoic, behenic), 2 – polyunsaturated (linoleicand, linolenic), 1 – monounsaturated (oleic). The greatest number of identified palmitic (6 232.6 mg/kg) and oleic (4 158 mg/kg) acids. It was also β-tocopherol (vitamin E) in an amount of 1 102.3 mg/kg and squalene (210.5 mg/kg) were identified. The development of drugs for the prevention and treatment of various diseases is perspective due to the presence and big number of identified compounds in the lipophilic extract of pumpkin pulp.
Authors and Affiliations
L. I. Vyshnevskaya, E. A. Degtyaryovа, Y. I. Bysaha
Keywords
Related Articles
- EP ID EP588082
- DOI -
- Views 72
- Downloads 0
Determination of the qualitative and quantitative content of hydroxycinnamic acids in Gentiana Cruciata L. herb
Gentiana cruciata L. is a herbaceous perennial flowering plant in the Gentianaceae family. This plant is widespread in the territory of Ukraine, namely the southern forest areas, forest-steppe and Crimea. Gentiana crucia...
Pharmaseutical development of polyion solutios for infusions. justification of presence of active pharmeceutical ingridients and additions
Modern manufacturing of any pharmaceutical treatment is impossible without a precise scrutiny of all factors that may influence on quality of end-product. As well quality has to be taken into account while developing thi...
Study of PEG-Filstim sub-acute toxicity
Febrile neutropenia caused by cytostatic therapy in the treatment of oncological diseases is a frequent complication, which results in enforced reduction in chemotherapy doses and lower effectiveness of the treatment. In...
Optimization of quality assurance system for pharmaceutical care based on the principles of risk management
In today's widespread use of medicines to ensure their efficacy and safety, physical and economic access to medicines, quality control, rational choice, the issues of pharmaceutical care are the topical issue of pharmace...
An influence of copper nanoparticles on the hemodynamics of rabbits in acute experiment
It is known that copper has a pronounced antibacterial, antifungal, and antiviral activity. Copper nanoparticles, in turn, are promising candidates for the development of a new class of drugs due to a combination of nano...