Study of red cell alloimmunisation in multigravida in RIMS hospital,Imphal
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Red cell alloimmunisation is the development of antibodies in response to foreign red cell antigens through transfusion or pregnancy. Females can be alloimmunised to red cell antigens by previous transfusions or transplantations and/or previous or current pregnancy.Red cell alloimmunisation in pregnancy is an immune disorder due to an incompatibility between maternal and fetal red blood cell antigens.In pregnant women,these antibodies may cross the placenta and cause haemolytic disease of the foetus and newborn(HDFN).Timely detection of such antibodies in antenatal women is essential for early management of HDFN.A prospective cross-sectional study was carried out on 200 multigravida attending antenatal clinic or admitted at the Department of Obstetrics and Gynaecology,RIMS,Imphal to find out the prevalence of red cell alloimmunisation and to study other factors which may contribute to alloimmunisation namely age,gravida,blood group and ethnicity.The women were grouped and typed for ABO and rhesus(Rh) D antigens by tube method and screened for alloantibodies by column agglutination technology.The medical history and detailed obstetric history of these women were reviewed and information recorded on any prior haemolytic disease of the foetus and newborn among siblings and/or blood transfusions.The overall prevalence of alloantibodies was 1%.There was a statistically significant difference between alloimmunisation rates in the Rh D-antigen negative and D-antigen positive women (20% versus 0.5%).The antibodies detected in this study were anti-E and anti-Lea .Red cell alloimmunisation is prevalent in around 1% of the multigravida women and significantly associated with gravida and ethnicity.As the other Rh and non-Rh group of antibodies were also identified,routine antibody screening and identification is recommended for all antenatal women.However,large-scale studies on pregnant women need to be done in order to collect sufficient evidence to be able to formulate guidelines regarding testing and interventional modalities for alloimmunisation in pregnancy.
Authors and Affiliations
Dr. Laikangbam Dayalaxmi, Dr. Sanjay N, Dr. Tashi Paleng, Dr. A. Barindra Sharma, Dr. M. Rameswar Singh, Dr. A. Meina Singh
Keywords
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- EP ID EP402371
- DOI 10.9790/0853-1710080408.
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