Study of Serum Amylase and Serum Cholinesterase in Organophosphorus Poisoning
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2016, Vol 5, Issue 2
Abstract
Background: Poisoning due to organophosphorus compounds is most commonly seen. Earlier plasma cholinesterase level was used to assess the severity of poisoning. Presently serum amylase is being recommended as a better indicator of severity. Aims and Objectives: To study plasma cholinesterase and serum amylase levels in acute organophosphorus and to correlate serum amylase levels with clinical severity and outcome. Material and Methods: A total of 80 patients in the study admitted to a tertiary care centre within 24 hours with a history of organophosphorus poisoning were included in study. Estimation of plasma cholinesterase and serum amylase was done at the time of admission, and on 3rd day and on 5th day. Results: Occurrence of organophosphorus poisoning was more common among age group 21-30 years and among males (57.5%). They were 25 (31.2%) farmers, 23 (28.8%) st u d e n ts, a n d 2 2 ( 2 7 . 5%) h o u s ewi v e s. Monocrotophos (45.0%) was commonly used compound. Mean value of plasma cholinesterase and serum amylase at admission are 3693 U/L, and 185.4 U/L. There was significant inhibition of plasma cholinesterase and elevation of serum amylase at admission with return to normal values on 5th day. Conclusion: Plasma cholinesterase inhibition <10% is associated with high degree of mortality. Hyperamylasemia >200 U/L has been associated with poor prognosis and proneness to respiratory failure.
Authors and Affiliations
Sharan Badiger , Vishok M
Keywords
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