Study of serum amylase levels in organophosphate poisoning
Journal Title: International Journal of Biomedical and Advance Research - Year 2017, Vol 8, Issue 12
Abstract
Background:Organophosphorus is poisoning producing clinical alterations in the serum amylase and lipase activity. Earlier plasma cholinesterase level was used to assess the severity of poisoning. Presently serum amylase is being recommended as a better indicator of severity. Aims and Objectives: The present study was undertaken to estimate serum amylase levels in acute organophosphate poisoningandto correlate serum amylase levels with outcome of patient. Methods: This cross sectional study was conducted in Shri Vasantrao Naik Government Medical College and Hospital, Yavatmal. A total of 120 patients with organophosphorus poisoning admitted to the hospital during the study period of 1st January 2017 to 30th November 2017 were included in the study. Biochemical evaluation which includes serum amylase, blood glucose, urea, creatinine, and liver function tests were analyzed. Results: In OP poisoning patients, the amylase levels were significantly elevated at the time of admission (178.21 U/L) and have shown a gradual remission with proper treatment. The mean amylase level in severely poisoned patients was 294.8 U/L.The bad prognostic factors, very well correlated with serum amylase levels were Pinpoint pupil- 297 U/L, Fasciculations-309 U/L, Severe secretions-321 U/L, CNS depession-334 U/L, Respiratory failure-359 U/L and Convulsions-398 U/L. The overall mean value of serum amylase was significantly higher in non-survivors Vs survivors (482.46 U/L Vs 148.34 U/L, p<0.0001). Conclusion: Serum amylase levels may be considered as a marker of Organophosphorous intoxication, since it enables the early recognition of severity and to identify those at risk of developing the complications of Organophosphorous poisoning.
Authors and Affiliations
Rohit N. Salame, Amar S. Wani
Keywords
Related Articles
- EP ID EP384622
- DOI 10.7439/ijbar.v8i12.4534
- Views 92
- Downloads 0
Visual evoked potential changes in diabetes mellitus
Background: Diabetes Mellitus (DM) a metabolic disorder is the most common cause of neuropathy. Electrophysiological studies are commonly employed to detect the neuropathy. The present study was undertaken to find out th...
Prevalence of hearing impairment among high risk neonates- A hospital based screening study
Background and objectives: Hearing loss present at birth is one of the major disabilities in childhood, the early detection of which can prevent further disability in speech, language and cognition. The prevalence of con...
Improved Spectrophotometric Pharmacopoeial Method for accurate Quantitation of Thiomersal content in Haemophilus influenzae type b (Hib)-TT Conjugate Vaccine
Vaccines remain one of the most effective ways to prevent infectious diseases globally. Accurate measurement of thiomersal content is an important parameter to ensure safety of vaccines though these vaccines are less in...
Supraclavicular Brachial Plexus Block with and without Dexamethasone as an Adjuvant to local anaesthetics: a Comparative Study
Aim and Objectives: To assess the effect of dexamethasone on onset and duration of anaesthesia as well as duration of analgesia when added to local anaesthetic solution for supraclavicular brachial plexus block. Methods...
Sutureless trabeculectomy as a substitute for conventional trabeculectomy in the management of primary open angle glaucoma
Aim: To assess the safety and efficacy of sutureless punch trabeculectomy, as a substitute for conventional scleral flap trabeculectomy, in the management of primary open angle glaucoma. Materials and methods: In a pros...