Study of serum lipid profile in premenopausal and postmenopausal women of Aurangabad district
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Menopause means permanent cessation of menstruation at the end of reproductive life due to loss of ovarian follicular activity. The effect of the hormonal changes associated with menopause on the serum lipid levels play important role in most cardiac disorders associated with menopause. Aims and Objectives: To measure Total cholesterol, Triglycerides, HDL in premenopausal cases were compared to postmenopausal women. Material and Methods: A group of 50 women, 25 premenopausal aged between 25-45 years and 25 postmenopausal aged between 55-65 years were studied after an informed consent from MGM medical college, Aurangabad..Total cholesterol, Triglycerides, HDL were measured by kit method on Analyser. And LDL and VLDL were calculated by Friedwald’s formula. Statistical analysis was done by student t-test. Mean values of serum Cholesterol, Triglycerides, HDL, LDL and VLDL in premenopausal cases were compared to postmenopausal women. Conclusion: TC and TG is found to be increased in post-menopausal women due to estrogen deficiency when compared to pre-menopausal women and is statistically significant (P < 0.05) .There was no statistical difference seen in HDL-C in pre and postmenopausal women. (P >0.05) In our study, the VLDL-C and LDL-C was increased in post-menopausal women as compared to pre-menopausal women and was statistically significant (P < 0.05). Due to the change in the lipid pattern and loss of cardioprotective effect of estrogen, post-menopausal women are at increased risk of developing cardiovascular disease. So it is important to educate each and every postmenopausal women to undergo screening for abnormal lipid profile.
Authors and Affiliations
Ruta Anandgaonkar, Deepali Vaishnav, Dhananjay Bhale
Keywords
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