Study of Serum Magenesium in Patients with Acute Myocardial Infarction.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 3
Abstract
Acute Coronary Syndrome is a major health burden worldwide and causes more deaths and disability and incurs greater economic cost than any other illness in the world. It is also a leading cause of death in India, and its contribution to mortality is rising [1,2]. Genetic factors, high-fat and energy-rich diet, Hypertension, Smoking, sedentary lifestyle, obesity, less exercise, insulin resistance and Type 2 Diabetes Mellitus are the most powerful risk factors for Acute Coronary Syndrome (ACS). Ischemic heart diseases is growing among low-income groups, but primary prevention has delayed the disease to later in life across socioeconomic groups [2]. Magnesium has several functions in the human body. It acts as a cofactor for more than 300 enzymes, regulating a number of fundamental functions such as muscle contraction, neuromuscular conduction, glycemic control, myocardial contraction, and blood pressure [3,4]. Magnesium is of major importance in the treatment of arrhythmia and coronary artery disease. Patients with coronary heart disease (CHD) suffer from magnesium deficiency. Oral combination therapy with magnesium and potassium improves endothelial function in these patients and reduce platelet dependent thrombosis [5,6]. Magnesium has been implicated in the pathogenesis of acute myocardial infarction and its complications like arrhythmias, it plays a significant role in other cardiovascular diseases as well [7]. Magnesium ions are considered essential for the maintenance of the functional integrity of the myocardium. Hypomagnesaemia is associated with an increased risk of cardiac arrhythmia by decreasing effect of magnesium against calcium at the atrioventricular node, which lead to unstable membrane potentials and conduction of impulses and increase the susceptibility to arrhythmia. [8] Also, myocardial infarction is one of the common causes of death at present where prognosis depends on multiple factor of which many still remain unexplained. This study is designed to know the relationship between serum magnesium levels and arrhythmias in patients with acute myocardial infarction. Aims and Objectives AIM: To estimate the level of serum magnesium in patients with acute myocardial infarction.
Authors and Affiliations
Dr. R. K. Jha
Keywords
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