STUDY OF SERUM MALONDIALDEHYDE, NITRIC OXIDE, VITAMIN E LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 2
Abstract
Background: Rheumatoid arthritis (RA) is a chronic progressive autoimmune disorder characterized by symmetric erosive synovitis and sometimes shows multisystem involvement. The long-term outcome of the disease is characterized by significant morbidity and increased mortality. Elevated free radical generations in inflamed joints and impaired antioxidant system have been implicated in RA. Nitric oxide (NO) can also induce tissue damage, especially after conversion into peroxynitrite radical (ONOO). Aims: To estimate the serum levels of MDA, Nitric Oxide (NO) and Vitamin E in patients with Rheumatoid Arthritis. Materials and Methods: The study includes 50 RA patients who were fulfilling the American Rheumatism Association 1987 revised criteria for classification of RA and 50 age and sex matched healthy subjects without any major illness were considered as controls. MDA, NO and Vitamin E were estimated in serum. Results: The estimated mean levels (mean ± SD) of serum MDA, NO, Vitamin E, in control group were 3.55  0.30, 36.23  7.03, 14.61  1.74, respectively and in patients with RA they were 5.39  0.79, 78.81  8.56, 10.56  1.72, respectively. The statistical analysis by unpaired t-test shows that the levels of serum MDA and NO significantly increased (p< 0.001) and the vitamin E levels were significantly decreased (p < 0.001) in RA patients when compared to healthy controls. Conclusion: The serum values of MDA, NO and Vitamin E all together provided fairly useful index of oxidative stress in RA patients. The results of current study support the concept of oxidative stress leading to tissue damage.
Authors and Affiliations
Jambale Triveni A| Assistant Professor, Department Of Biochemistry, ESIC MC, Gulbarga, India, Corresponding author email: trivenijambale@gmail.com, Halyal SS| Department of Biochemistry, SIMS, Tumkur, Karnataka, India, Jayaprakash Murthy DS| Department of Biochemistry, OMC, Bangalore, Karnataka, India
Keywords
Related Articles
- EP ID EP11166
- DOI 10.5958/j.2319-5886.3.2.067
- Views 317
- Downloads 15
The survey of the relationship between meta-cognitive selfregulation with the test anxiety in the city of Urmia’s Medical Sciences University Students in 2016
The university students with higher levels of test anxiety have been shown to have lower cognitive and meta-cognitive performances and therefore they act weakly on their examinations and tests. According to the role pla...
Taxonomy level of pediatrics exams and psychometric characteristics of MCQ test in year 2014
Educational assessment not only needs to examine the test items making up the test but also to evaluate the level of learning of test takers. The purpose of this research was to examine the multiple choice items indices...
Tissue Doppler Imaging in Cardiology Nowadays: Clinical Applications
Echocardiography is a routine test in cardiology nowadays and Tissue Doppler imaging (TDI) is particularly useful for evaluating myocardial tissue motion; compared to strain imaging, TDI has a higher temporal resolution...
Effect of Anti-Cholinergics with Tamsulosin for Treating Benign Prostate Hyperplasia Patients with an Overactive Bladder: A Clinico-Comparative Study
Objective: Overactive bladder (OAB) symptoms are due to detrusor over activity (DOA) which is characterized by involuntary detrusor contractions during bladder flling. It may co-exist with BOO due to benign prostate hyp...
Assessment of Morphological Variations and its Specifc Location on the Surface of Adult Human Liver in Ethiopian Cadavers University of Gondar, Bahir Dar University, Addis Ababa University, St. Paulos Medical School and Hawassa University, Ethiopia
Background: Liver is the second largest organ next to skin and located in right hypochondrium, epigastrium and may extend to left hypochondrium in upper abdominal cavity. It accounts 2% to 3% of total body weight of ind...