Study of Serum Paraoxonase Levels in Type 2 Diabetes Mellitus Patients & Suggests Risk of Cardiovascular Disease
Journal Title: IJSR-International Journal Of Scientific Research - Year 2016, Vol 5, Issue 11
Abstract
Background and Objectives: Diabetes, a lifelong progressive disease, with metabolic dysregulation, is associated with increased risk of cardiovascular complications. Paraoxonase (PON), an enzyme associated with high-density lipoprotein (HDL) is known to modulate the antioxidant and anti-inflammatory role of HDL and may have a protective role in the prevention of these complications. The present study was undertaken to evaluate serum PON, paraoxon as reacting substance and serum lipid profile in Type 2 diabetes mellitus (DM). Materials and Methods: The study group consists of 30 Healthy Controls, 30 patients with diabetes mellitus with CAD, 30 non-diabetic patients with CAD, 30 Patients with Diabetes mellitus without clinical Coronary artery disease. Lipid profile was estimated by enzymatic methods using analysed on Biochemistry Autoanalyser (AU480) in Central Clinical Laboratory, and serum PON by spectrophotometric method. Results: Total cholesterol levels are highly increased in group II & IV as compared to group I (P<0.001). Group III shows significant increase in Total cholesterol as compared to group I (P<0.05). T.G. levels are highly increased in study group (i.e. group II, group III, & group IV) as compared to group I (P<0.001). The levels of LDL are significantly increased in study groups as compared to control group (P<0.05). The mean levels of HDL significantly decreased in study group (i.e. group II, group III, & group IV) as compared to group I (P<0.05). PON1 levels is significantly decreased in study groups ((i.e. group II, group III, & group IV) as compared to control group I (P<0.001). Conclusion: Our study demonstrates that Type 2 DM patients have significantly lower levels of PON activity than the healthy control. Serum Paraoxonase levels were decreased in patients with diabetes & CAD.PON activity directly correlation with HDL levels. This may reduce the protective role of HDL and increases the susceptibility of cardiovascular complications.
Authors and Affiliations
MM Shah, Dr Z. G. Badade, Dr. S. K. kaul
Keywords
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