STUDY OF SERUM TOTAL THIOL LEVELS AND LIPID PEROXIDATION AS INDICATOR OF OXIDATIVE STRESS IN PATIENTS OF ACUTE CENTRAL SEROUS RETINOPATHY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 1
Abstract
BACKGROUND ''Central Serous Retinopathy (CSCR) is an idiopathic, commonly encountered retinal disease, in which stress has been implicated to play a possible role. Our study aimed to determine the role of oxidative stress in the pathogenesis of the disease by comparing the serum levels of total thiols and TBARS in patients of CSCR and normal controls.'' The aim of this study was to determine the level of plasma total thiol and malondialdehyde (MDA) in patients of central serous chorioretinopathy (CSCR) and compare these parameters with that of normal individuals to evaluate the relevance of oxidative stress in the disease pathogenesis. MATERIALS AND METHODS A prospective cross-sectional study was performed that included 30 patients of CSCR and 30 normal patients as controls. Serum total thiol and malondialdehyde levels were measured and compared between the two groups. Correlation between serum total thiol and malondialdehyde with best corrected visual acuity, central minimum macular thickness at the foveola (CMT) and average macular thickness (AMT) was done using Pearson’s correlation coefficient. RESULTS Serum total thiol levels were lower (370.9+53.34 mM) compared to the control group (761.5+25.44 mM), with p<0.01. Serum MDA levels were higher (7.52 + 0.68 µM) than the control group (2.03+0.112 µM), with p value <0.01. In CSCR, correlation analysis tests showed a strong positive correlation (p<0.05) between the elevated levels of MDA with CMT (r = 0.377) and AMT (r =0.398) and a very strong negative correlation (p<0.01) between serum total thiol levels with CMT (r = - 0.834) and AMT (r = -0.73). Regression analysis showed that a decrease in total thiol levels can be a strong predictor (beta -0.811) of increase in CMT in CSCR (p<0.01) while increase in MDA levels is not a significant predictor (beta 0.057). The overall model fit was adjusted R2 =0.675 (p<0.01). CONCLUSION A higher level of total thiol and a lower level of MDA were found in CSCR as compared with normal controls. Total thiols can be useful in the prediction and diagnosis of the severity of CSCR.
Authors and Affiliations
Rakhi Bandopadhyay, Tanima Mandal, Pinaki Sarkar
Keywords
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- EP ID EP553015
- DOI 10.14260/jemds/2019/5
- Views 51
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