Study of Serum Uric Acid Level in Acute Coronary Syndrome in Nepalese Subjects

Apply

Study of Serum Uric Acid Level in Acute Coronary Syndrome in Nepalese Subjects

Journal Title: Trends Journal of Sciences Research - Year 2019, Vol 4, Issue 1

Abstract

At present, cardiovascular diseases are global health problems responsible for 17.3 million deaths per year and adding extra burden in developing countries like Nepal. Studies show that serum uric acid (SUA) can result in endothelial dysfunction which can lead to vascular disease like stroke. In this study, we determined serum uric acid levels in patients with acute coronary syndrome (ACS) and assess its risk factors. A cross sectional study was conducted in 82 patients with ACS who fulfilled the inclusion criteria included in the study and their serum uric acid level were investigated. It was found that 51 (62.2%) were males and 31 (37.8%) were females. Mean age in study population was 60.26 ± 11.34 years. Majority of the population belongs to 56-65 years age group. The mean uric acid level of our study population was 6.03 ± 1.50 mg/dl (male = 5.92 ± 1.72, female = 6.64 ± 1.53). SUA ≥ 7 mg/dl was maximum in 56-65 years age group and there was no association between age and SUA (P value = 0.146). Over half of the study population were hypertensive i.e. 42 (51.21%) and smoker i.e. 43 (52.43%). It showed association between SUA and ACS (P value = 0.003). Among those having diabetes, maximum have SUA ≥ 7 mg/dl i.e. 17 (47.22%). Among those having high cholesterol level, male have higher incidence than female with no association between T. Cholesterol and gender (P value = 0.49). The mean value of T. Cholesterol was 189.83 ± 46.81 mg/dl (male = 198.78 ± 55.19 mg/dl, female = 202.30 ± 54.92 mg/dl) with (P value = 0.52). In conclusion, the mean age of ACS patients was 60.26 years, with the peak incidence at the age of 56-65 years. The ACS had male predominance. The potential risk factors of ACS were: Age >56 years (65.83%), male sex (62.2%), dyslipidemia (35.36%, hypertension (51.2%), diabetes mellitus (43.9%), smoking (52.4%) and alcohol consumption (39%). Among these SUA significantly associated with risk factors were- Sex, Diabetes Mellitus, T. Cholesterol. There was association between serum uric acid level and ACS patients. Hypertension and smoking constitutes one of the major risk factor for ACS in study population.

Authors and Affiliations

Manoj Karki, Nabin Rokaya, Prabin Khatri, Aakash Shahi, Alok Sah

Keywords

Red Cell Distribution Width and Neutrophil/lymphocyte Ratio in Bare Metal Coronary Artery Stent Restenosis

Background: Coronary stents are commonly used to treat obstructive coronary artery disease. It is currently difficult to reliably predict in-stent restenosis. The aim of this study was to examine the relationship between...

Thermal Stability of Ultrafine Grained CuCrZr Alloy Produced by Continuous Extrusion

The Cu-0.36Cr-0.15Zr alloy was prepared by solid solution, continuous extrusion and cold deformation. The microstructural evolution, microhardness and the thermal analysis were examined for the alloy after annealing trea...

Chemical and Biological Properties of Sodium Alginates Isolated from Tow Brown Algae Dictyopteris Membranaceae and Padina Pavonica

Polysaccharides are known to have interesting biological activities. To date polysaccharides extracted from Tunisian seaweed have not been fully studied. In this paper we tried to isolate sodium alginate from two brown a...

Study of Serum Uric Acid Level in Acute Coronary Syndrome in Nepalese Subjects

Effectiveness of Peritoneal Dialysis in Management of Acute Hyperthermia after On-Pump Heart Surgery in Infants

Introduction: Acute hyperthermia is a common complication in the first 24 hours after open heart surgery with the incidence of 12% to 73%. The aim of this study was to evaluate the efficiency of postoperative peritoneal...

EP ID EP438284
DOI 10.31586/Cardiology.0401.04
Views 53
Downloads 0