Study of Soluble Transferrin Receptor and Soluble Transferrin Receptor - Log Ferritin Index in Differentiating between Iron Deficiency Anemia, Anemia of Chronic Disease and Combined Anemias
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Anemia can be defined as reduced oxygen carrying capacity of blood due to various reasons and iron deficiency is the commonest cause of anemia. However it is not easy to distinguish between iron deficiency anemia, anemia of chronic disease and combined iron deficiency anemia and anemia of chronic disease (COMBI anemia) using the present iron profile parameters alone. Bone marrow being an invasive procedure there is a need to find better non invasive methods. Hence this study was undertaken. Material and methods: This was a prospective observational study and the study population was divided into the three respective anemia groups. All the included patients were evaluated clinically and routine investigations were done along with iron profile. Subsequently serum soluble transferrin receptor (sTfr) evaluation was done by ElISA method and index of sTfr and log ferritin was calculated. Statistical ananlysis was performed. Results: Values of sTfr and sTfr- log ferritin index showed a significant difference among the three groups. The sTFR of iron deficiency anemia patients was significantly higher as compared to anemia of chronic disease (p<0.001) and combined anemia (p<0.001). Patients with combined anemia also had a significantly higher sTFR as compared to the anemia of chronic disease (p<0.001). The sTfr- log ferritin index of iron deficiency anemia patients was significantly higher as compared to anemia of chronic disease (p<0.001) and combined anemia (p<0.001). Patients with combined anemia also had a significantly higher index as compared to the anemia of chronic disease (p<0.001). Conclusion:Thus it was concluded that these two parameters, i.e. sTfr and sTfr- log ferritin index, have a promising role in differentiating between the three types of anemias.
Authors and Affiliations
S Riaz Mehdi, Farhana A, Noorin Zaidi, Imran Rizvi
Keywords
Related Articles
- EP ID EP424238
- DOI -
- Views 82
- Downloads 0
Early Post – Operative Intraocular Pressure Rise between Phacoemulsification and Phacotrabeculectomy in Primary Open Angle Glaucoma Patients: A Comparison
Introduction: Phacoemulsification with intraocular lens implantation and triple procedure (phacoemulsification with intraocular lens implantation with trabeculectomy) are associated with a significant intraocular pressur...
Aerobic Bacterial Profile of Diabetic foot and its Antibiogram in RIMS, Ranchi - a Tertiary Care Hospital
Introduction: Diabetic foot is the most serious complications of diabetes. Hyperglycemia impairs body defense mechanism, leads to increase infection rate. Thus for proper management it is necessary to know about most eff...
Chemotherapy Improves Quality of Life and Prolongs Survival in Patients of Lung Cancer
Lung cancer is the most frequently diagnosed cancer and the foremost cause of cancer-related deaths. Particularly, lung cancer has an estimated incidence of 1.6 million new cases every year. Despite the various advances...
Topical Steroid Abuse: Clinicoepidemiological Profile
Introduction: Topical corticosteroids are today among the most commonly prescribed medications in dermatology clinics. Steroid abuse is a common problem due to easy availability of steroid creams as over-the-counter drug...
A Cross Sectional Study to Evaluate Role of Magnetic Resonance Imaging in Ligament Injuries of Knee Joint in a Tertiary Healthcare Institute
Introduction: Ligaments being the most important supporting structures injuries of ligaments and menisci are extremely common especially in active individuals like athletes. However ligament injury of knee in young due t...