Study of Soluble Transferrin Receptor and Soluble Transferrin Receptor - Log Ferritin Index in Differentiating between Iron Deficiency Anemia, Anemia of Chronic Disease and Combined Anemias
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Anemia can be defined as reduced oxygen carrying capacity of blood due to various reasons and iron deficiency is the commonest cause of anemia. However it is not easy to distinguish between iron deficiency anemia, anemia of chronic disease and combined iron deficiency anemia and anemia of chronic disease (COMBI anemia) using the present iron profile parameters alone. Bone marrow being an invasive procedure there is a need to find better non invasive methods. Hence this study was undertaken. Material and methods: This was a prospective observational study and the study population was divided into the three respective anemia groups. All the included patients were evaluated clinically and routine investigations were done along with iron profile. Subsequently serum soluble transferrin receptor (sTfr) evaluation was done by ElISA method and index of sTfr and log ferritin was calculated. Statistical ananlysis was performed. Results: Values of sTfr and sTfr- log ferritin index showed a significant difference among the three groups. The sTFR of iron deficiency anemia patients was significantly higher as compared to anemia of chronic disease (p<0.001) and combined anemia (p<0.001). Patients with combined anemia also had a significantly higher sTFR as compared to the anemia of chronic disease (p<0.001). The sTfr- log ferritin index of iron deficiency anemia patients was significantly higher as compared to anemia of chronic disease (p<0.001) and combined anemia (p<0.001). Patients with combined anemia also had a significantly higher index as compared to the anemia of chronic disease (p<0.001). Conclusion:Thus it was concluded that these two parameters, i.e. sTfr and sTfr- log ferritin index, have a promising role in differentiating between the three types of anemias.
Authors and Affiliations
S Riaz Mehdi, Farhana A, Noorin Zaidi, Imran Rizvi
Keywords
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