Study of the antileukemic activity of Mimosa caesalpiniifolia Benth. ethanolic extract and fractions
Journal Title: Trends in Phytochemical Research - Year 2018, Vol 2, Issue 3
Abstract
Mimosa caesalpiniifolia Benth. is a native plant to northeastern Brazil, traditionally used in folk medicine, with several pharmacological activities reported including antibacterial, anti-inflammatory, and antitumor. The present study evaluated the antileukemic potential of M. caesalpiniifolia Benth. ethanolic extract (EtOH) and its n-hexanic (HexF) and dichloromethane (DCMF) fractions. Previous analysis by our team revealed the constituents of high relative abundance in EtOH, HexF, and DCMF, like phytol (11.7%), lupeol (14.7%), and betulinic acid (70.3%), respectively. In the MTT cell viability test, EtOH, HexF, and DCMF induced dose-dependent cytotoxicity in human chronic myeloid cells (K562), with IC50 of 153.6 ± 0.1, 118.40 ± 0.2, and 40.0 ± 0.1 μg/mL, respectively (p<0.05). Additionally, DCMF (6-800 μg/mL) presented minor toxicity against normal human erythrocytes and murine macrophage cells. DCMF induced similar antileukemic effects (IC50=64.2 ± 5.0 μg/mL) against human acute myeloid cells (HL-60). However, it did not exert antitumor activity on murine sarcoma (S180) cells (p>0.05).
Authors and Affiliations
Gabriele Taumaturgo Mororó; José Roberto de Oliveira Ferreira; Michel Mualén de Morais Alves; Nayana Bruna Nery Monção; Laís Campos Teixeira de Carvalho-Gonçalves; Antônia Maria das Graças Lopes Citó; Paulo Michel Pinheiro Ferreira; Fernando Aécio de Amorim Carvalho; Juan Carlos Ramos Gonçalves
Keywords
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