STUDY OF THE CLINICAL PRESENTATION OF APLASTIC ANEMIA WITH SPECIAL REFERENCE TO ASSOCIATION WITH PARVOVIRUS B19 INFECTION- A TERTIARY CARE HOSPITAL BASED STUDY
Journal Title: PARIPEX-Indian Journal of Research - Year 2019, Vol 8, Issue 7
Abstract
Aplastic anemia is a disease of bone marrow failure characterized by pancytopenia with marrow hypocellularity. Possible etiologies that have been implicated includes drugs, irradiation and preceding viral infections as non-A, non-B, non-C hepatitis, Epstein Barr virus, cytomegalovirus, HIV and rubella. Most cases of parvovirus B19 infection are asymptomatic or present with flu like symptoms. Severe aplastic anemia has been reported in a previously healthy boy without any underlying diseases, following asymptomatic infection with parvovirus B19. A total of 22 patients with aplastic anemia admitted in medicine ward were studied. Patient with Hb less than 10gm%, total count less than 4000/cumm, platelet counts less than 1, 00,000/cumm were included. Bone marrow aspiration was done in all cases. Serum samples taken from each patient tested for parvovirus antibodies and viral DNA. Parvovirus B19 IgM detected in 22.7% cases and Parvovirus B19 DNA in 18.18% cases.
Authors and Affiliations
Dr. B. C. Kalita, Dr. Alal Uddin, Dr. (Mrs. ) S. L. Das, Dr. S. Kar
Keywords
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