Study of the correlation between red blood cell distribution width，systemic immune-inflammation index with major depressive disorder
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 7
Abstract
[Objective] To investigate the correlation between red blood cell distribution width (RDW), systemic immune-inflammation index (SII) and major depressive disorder (MDD). [Methods] The clinical data of 176 MDD patients hospitalized in the clinical psychology department of our hospital from 2020 to 2022 and 209 non-MDD comparators who were routinely examined in Hebei General Hospital were retrospectively analyzed. Blood analysis was conducted to obtain values of RDW, SII, and red blood cell distribution width/platelet ratio (RPR). The data was used to plot the receiver operator characteristic (ROC) curve to determine the optimal threshold and the area under the curve (AUC) for RDW to discriminate between patients and controls. [Result] Patients in the MDD group had significantly higher RDW [median and quartiles: 13.20 (12.70, 13.98) vs. 12.80 (12.40, 13.35)], and SII levels [median and quartiles 510.87 (350.95, 878.12) vs. 405.33 (313.74, 539.92)] compared with those in non-MDD group (P<0.05). There was no significant difference in RPR between the two groups (P>0.05). Multifactorial logistic regression analysis showed that RDW was positively correlated with MDD after adjusting for confounders (OR=3.086, 95%CI: 1.926-4.944). ROC curve showed that the optimal threshold for RDW to differentiate the risk of developing MDD was 12.85, with an AUC of 0.647 (95%CI: 0.592-0.702; P<0.001). [Conclusion] Present study shows that high RDW is a risk factor for the occurrence of MDD and an important parameter for the risk of developing depression.
Authors and Affiliations
Man JIN, Hao LIANG, Shipan ZHANG, Xueru ZHANG, Peng JING, Yue YANG, Chunyang WANG, Peiyuan. LYU
Keywords
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- EP ID EP750519
- DOI 10.3969/j.issn.1002-0152.2024.07.003
- Views 28
- Downloads 0
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