Study of the Effect of HAART on Lipid Profile in HIV Positive Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Human immunodeficiency Virus (HIV) infection is pandemic worldwide). Patients with HIV infection were reported to have hypocholesterolemia with or without hypertriglyceridemia however the mechanism of decrease in cholesterol levels is not known. Infections can increase serum triglycerides levels by decreasing clearance of circulating lipoprotein levels as process seems to inhibit the lipoprotein lipase activity or stimulating hepatic lipid synthesis through increase in either hepatic fatty acid synthesis or esterification of fatty acids derived from lipolysis. Keeping in view of the various biochemical abnormalities associated with lipid metabolism, our research was inclined to assess the lipid profile in HIV positive cases, with an attempt to further elucidate more features of HIV disease which erupts as acquired immunodeficiency syndrome (AIDS) linking any possible involvement of lipid profile in disease progression of AIDS. A hospital based descriptive cross-sectional study. Conducted at ART centre, Department of Medicine, Hamidia Hospital, Gandhi Medical College, and Bhopal. Study participants were between age group 20 to 50 years those who newly diagnosed cases of HIV/AIDS in whom decision about ART was yet to be taken and patients on HAART whose initial lipid profile is available in records. Patients participating in study were thoroughly examined with standard clinical methods and assigned WHO clinical staging and subjected to various laboratory investigations. Mean age being (±SEM) 34.85±2.46 years. Highest number of the patients was of stage III disease with number of 102(51%). Out of all 200 patients 51 registered patients were HAART naïve and never started ART during study. Patients on HAART shows statistically significant (p<0.05) for Total Cholesterol (TC) which increased upto 242.6 ± 1.42 (Mean±SEM) from its baseline value of 240.3 ± 1.09. Serum Triglyserides also shown significant (p<0.05) rise from 137.5 ± 2.22 to 140.7 ± 2.88 (Mean±SEM). In lipid profile parameters all parameters raised from HAART to patients on HAART group but significant increase was seen for TC in HAART naïve group(p<0.05), for TC, S.TG (p<0.05) in Regimen I treated patients, same for the Regimen II treated patients, TC (p<0.005), S.TG (p<0.0001), HDLC (p<0.05) in Regimen II treated Patients and for TC, S.TG, HDLc, LDL and VLDL (p<0.005, p<0.005, p<0.05, p<0.005, p<0.05,) in Regiment III treated patients.
Authors and Affiliations
Dr Alok Chandra Prakash, Dr. Anil Sejwar, Dr. Gopal Krishna
Keywords
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