STUDY OF THE IMPACT OF THE NEW METHYLTHEOPHYLLINE DERIVATIVE ON THE KIDNEYS FUNCTIONAL STATE OF THE RATS ON THE BACKGROUND OF SPONTANEOUS DIURESIS
Journal Title: ВЕТЕРИНАРІЯ, ТЕХНОЛОГІЇ ТВАРИННИЦТВА ТА ПРИРОДОКОРИСТУВАННЯ - Year 2018, Vol 2, Issue
Abstract
The results concerning the impact of the new methyltheophylline derivative -7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline on the activity of the kidneys in rats under conditions of spontaneous diuresis and figuring out some of the mechanisms of diuretic action for compounds. Research conducted on the white breed less rats of both sexes. Study of diuretic activity of 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline was carried out by E. B. Berchin. The content of electrolytes was determined using flame photometry, and an amount of creatinine formed by Folin’s method. The obtained data was calculated by techniques of nonparametric statistics using Student’s criterion (Lapach, Chubenko, & Babich, 2000). Based on the study of single and multiple (within seven days) introduction of 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline on the functional condition of kidneys in conditions of free access to the water and spontaneous diuresis, it was found, that single introduction of a dose of 30 mg/kg and under conditions of free access to water, 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline reduces drinking excitability to 2.4% (p<0.05), increases diuresis in 2.77 times (p<0.05), the concentration and excretion of sodium ions in 1.23 times (p < 0.05) and 3.05 times (p < 0.05), respectively; causes the growth of concentration and urinary excretion of potassium ions in 1.07 times (p < 0.05) and 2.68 (p < 0.05); increases the excretion of creatinine in 2.38 times (p<0.05) and slightly reduces the concentration of creatinine (7, 5%; p < 0.05). Observation of rats after applying of the 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline demonstrated, that on the 2nd day the indices almost returned to control values. Under conditions of multiple introduction of the studied compound the statistically reliable increase of urine output was observed. Average daily diuresis per seven-day period of 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline exceeded control period data in 2.77 times (p<0.05). After the cancelation of 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline the decrese in diuresis was noted. Reference drug hydrochlorothiazide in a dose of 25 mg/kg have spontaneous diuresis on only 70% (p<0.05), and the excretion of creatinine increased to 7.4% in comparison with control. Efficiency comparison of 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline with hydrochlorothiazide indicates a greater capacity of the last to excrete potassium (20.7%) and decrease urine sodium ions excretion (11.3%). It was determined, that in the conditions of spontaneous diuresis urination effected by 7-benzoylmethyl-8-(furyl-2)-methylaminotheophylline more definitely increases after reintroduction of it; prolonged application in the conditions of spontaneous diuresis, tested compound promotes the excretion of sodium ions and to a lesser extent — potassium ions.
Authors and Affiliations
V. I. Korniyenko, E. V. Ladohubets, O. V. Ponomarenko, I. V. Harkusha, E. A. Duchenko
Keywords
Related Articles
- EP ID EP454262
- DOI 10.31890/vttp.2018.02.12
- Views 111
- Downloads 0
SOME MACROSCOPIC CHANGES IN THE INTERNAL ORGANS OF THE DOGS, WHO DIED FROM THE COMPOSIONS CAUSED BY THE PYOMETRA
At least once in a lifetime, but each of the dog owners spoke with a veterinarian. This is due to the fact that the modern realities of life sometimes negatively affect the dog as well as people, therefore, the immunity...
FEATURES OF FORMATION OF INDICATORS OF LIFETIME USE OF COWS OF THE BROWN BREEDS OF THE NORTH-EAST OF UKRAINE
Recently, scientists have paid great attention to the study of identifying the factors that determine the indicators of lifetime use of cows. This issue is particularly relevant in the context of the widespread use of bu...
EFFICIENCY OF TREATMENT OF SPORTS HORSES WITH MYOCARDIAL DYSTROPHY
Recent years are characterized by close attention to diseases, which are often a component of metabolic syndrome (MS). The pathogenetic multifacency of the MS and the clinical heterogeneity of the manifestations of the d...
CHARACTERISTICS OF MICROBIOLOGICAL PARAMETERS OF THE FROZEN FISH IN THE PRESENCE OF ANTIBIOTIC RESIDUES
Due to its high nutritional and biological value, fish is a good nutrient for development of microorganisms, therefore, the conditions and terms of its storage require appropriate temperature regimes to stop the growth o...
Фізіологічний стан та біохімічні показники крові ремонтних телиць при використанні в раціонах тритикалево-викової сумішки
Досліджено біохімічні показники крові ремонтних телиць, яким згодовували тритикалево-викову сумішку зеленої маси та сіна. Наведені дані вказують на більш інтенсивний обмін речовин в організмі молодняку великої рогатої х...