STUDY OF THE INCLUSION BEHAVIOUR OF Î’-CYCLODEXTRIN WITH ZIPRASIDONE AND ITS PHARMACEUTICAL APPLICATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
The inclusion complex of the slight water solubility ziprasidone (ZIP) with β-cyclodextrin (β-CD) was investigated by spectrofluorimetry. Influence of pH and β-CD concentration on the fluorescence spectra was reported. The obtained results exhibited that the ZIP was encapsulated in β-CD cavity to form a 1:1 stoichiometry host-guest complex. The inclusion constant was confirmed by Benesi-Hildebrand method. The inclusion complex formation was also confirmed by scanning electron microscopy SEM. Based on the remarkable enhancement of the fluorescence intensity of ZIP in the presence of β-CD a new spectrofluorimetric method for the determination of ZIP was developed. In order to obtain the maximum fluorescence several experimental conditions were optimized. The linear range was 0.5-100 ng mL-1and correlation coefficient was 0.9992. The detection limit was 0.2 ng mL-1. The proposed method was successfully applied to the analysis of ZIP in pure and pharmaceutical dosage forms with the satisfactory results.
Authors and Affiliations
Wieslawa Misiuk
Keywords
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