STUDY OF THE KINETICS AND MECHANISM OF OXIDATION REACTION OF AMBROXOL HYDROCHLORIDE DRUG WITH CHLORAMINE-T IN NAOH MEDIUM
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 12
Abstract
Kinetics of oxidation of Ambroxol Hydrochloride (ABL) drug by Chloramine-T (CAT) in NaOH at 308 K has been investigated by iodometry. The reaction showed first-order dependence of rate on [CAT] and [ABL]o and inverse fractional-order dependence on [OH-] and [PTS]. The stoichiometry of the reaction was found to be 1:1 with respect to the substrate and oxidant respectively. The oxidation products were identified by spectral and FTIR analysis. Variation of ionic strength had no effect on the rate. Addition of p-toluenesulfonamide (PTS) retarded the rate of reaction. Activation parameters have been computed. Probable mechanism and the derived rate law have been proposed to explain the observed kinetic results.
Authors and Affiliations
Dr. Asha Iyengar
Keywords
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