Study of the Levels of Serum Prolactin in Childhood Seizure Disorder
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Background: Seizure disorder is the most common neurological problem in children.Prolonged Seizure activity leads to failure of cerebral auto regulation. Objective: This study aimed to determine the role of Serum Prolactin level in different type of Seizures and Seizure like activity in children, and correlate with the post-ictal duration. Materials and Methods: This study was carried out in the department of Pediatrics and Neonatology, RIMS, Ranchi from March 2015 to September 2016. The present study was done on 75 cases of study group and 25 cases of control. The study group was divided into three groups of 25 cases each: Group I: (Generalised Tonic Clonic Seizures, Complex Partial Seizure, or Simple Partial Seizure).Group II: (Febrile Convulsion).Group III : (conditions mimicking seizures).Blood was collected within 2 hours of seizure and prolactin levels assayed. Results: Prolactin levels were significantly high only within Group I .Prolactin levels highest attained within 10 minutes and baseline levels were attained by 100 minutes. But in other group prolactin level was within normal limit. Conclusion: The clinical usefulness of post-ictal prolactin estimation is restricted to the positive diagnosis of epileptic seizures. A high Prolactin level within 100 minutes of a seizure is suggestive of GTCS, or Complex partial seizure having occurred.
Authors and Affiliations
Dr. Rajeeva Mishra, Dr. Bhardwaj Narayan Chaudhary
Keywords
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- EP ID EP598030
- DOI 10.9790/0853-1605094850.
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