Study of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma

Journal Title: Revista de Medicină Militară - Year 2017, Vol 0, Issue 3

Abstract

Pathologists observed the presence of tumor infiltrating lymphocytes (TILs) in solid tumors many years before the research focus shifted from cancer cells to the tumoral microenvironment. In lung adenocarcinoma TILs vary in number, phenotype and distribution. Our study investigate the type and distribution of TILs regarding the stage of disease and histological subtype in 27 cases of lung adenocarcinoma. By immunohistochemistry we evaluated semi-quantitatively CD3, CD8 and cyclin D1. We have found that CD3+CD8- lymphocytes prevail at the invasive margin and in tumoral stroma. Cyclin D1 was diffusely positive in tumoral cells in all the five cases of lepidic type of lung adenocarcinoma. In other histological types cyclin D1 was focally positive, most at the margin of the tumor irrespective of the presence or absence of TILs

Authors and Affiliations

Andreea Mihai, George Simion, Florin Chirculescu, Maria Sajin

Keywords

Related Articles

Autologous versus synthesis materials used in the surgical closure of CSF leak

The evolution of the endoscopic skull base surgery in the last ten years had led to the development of new surgical reconstructive techniques. In the endoscopic reconstructive surgery of the CSF leaks both synthesis and...

A case of acne fulminans

Background and aim: Acne fulminans is a rare and severe form of acne which usually appears in young men with a personal history of mild to moderate acne. It is characterized by a sudden onset with nodules and ulcerative...

Renal angiomyolipoma – a short review of the literature

Renal angiomyolipomas (AML) are the most common benign renal tumors. By containing an important amount of fat tissue they are easily identifiable on CT and MRI images, thus no biopsy should be needed for a diagnosis. How...

From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease

Chronic liver disease is a late stage of progressive hepatic fibrosis. It consists of functional and structural disruptions in most chronic liver diseases. An accurate diagnosis allows us to establish the degree of fibro...

Stress management for optimization of organizational activity

Stress is a constant presence in our lives, whether we analyze it in professional, social or family terms. This daily reality creates a state of tension, strain and discomfort, causing significant changes in physical and...

Download PDF file
  • EP ID EP291279
  • DOI -
  • Views 112
  • Downloads 0

How To Cite

Andreea Mihai, George Simion, Florin Chirculescu, Maria Sajin (2017). Study of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma. Revista de Medicină Militară, 0(3), 24-28. https://europub.co.uk/articles/-A-291279