Study of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma
Journal Title: Revista de Medicină Militară - Year 2017, Vol 0, Issue 3
Abstract
Pathologists observed the presence of tumor infiltrating lymphocytes (TILs) in solid tumors many years before the research focus shifted from cancer cells to the tumoral microenvironment. In lung adenocarcinoma TILs vary in number, phenotype and distribution. Our study investigate the type and distribution of TILs regarding the stage of disease and histological subtype in 27 cases of lung adenocarcinoma. By immunohistochemistry we evaluated semi-quantitatively CD3, CD8 and cyclin D1. We have found that CD3+CD8- lymphocytes prevail at the invasive margin and in tumoral stroma. Cyclin D1 was diffusely positive in tumoral cells in all the five cases of lepidic type of lung adenocarcinoma. In other histological types cyclin D1 was focally positive, most at the margin of the tumor irrespective of the presence or absence of TILs
Authors and Affiliations
Andreea Mihai, George Simion, Florin Chirculescu, Maria Sajin
Keywords
Related Articles
- EP ID EP291279
- DOI -
- Views 97
- Downloads 0
Hepatic hydatid cysts
-
Rare case of Stevens-Johnson-TEN overlap syndrome caused by mycotoxins
Mushroom poisoning is rarely associated with skin involvement. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous reactions, characterized by extensive necrosis. SJS/TE...
Atypical Cogan syndrome; case report
Cogan syndrome is a rare disease characterized by the concomitance of non-syphilitic interstitial keratitis with Meniere-like vestibulo-auditory symptoms. There are criteria for the diagnosis of both typical and atypical...
PancreaticFest 2015, annual EUS international workshop
-
Proceedings of the 21st Congress of Balkan Military Medical Committee
-