Study of the use of Heparin Sulphate injection in irrigation solution intraoperatively in cataract surgery and its effect on intraocular inflammation and cellular reaction
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 11
Abstract
Background: Inflammation after cataract surgery is due to breakdown of the blood-aqueous barrier and release of prostaglandins which leads to cellular infiltration of the anterior chamber. The post-surgical increase in the permeability of blood-aqueous barrier appears to be related to a release of Prostaglandin E2. Postoperative inflammation continues to be a cause of patient discomfort and pain and if left untreated, it can lead to formation of synechiae, increased intraocular pressure and in some cases, suboptimal visual results secondary to cystoids macular edema. Aim of the study: To evaluate the effectiveness of heparin sulphate in irrigating solution in controlling inflammation following an uneventful cataract surgery with intraocular lens implantation in a large sample double blinded trial. Materials and method: A prospective, randomized, double blinded comparative study was carried out on 200 adult patients at a tertiary care centre. A detailed history of disease and prior treatment was taken. Atleast 5 visits were scheduled on postoperative days 1, 4, 7, 15 and 30. The cases were selected from patients who underwent uncomplicated cataract surgery with posterior chamber intraocular lens (PCIOL) implantation in the capsular bag. Results: We found that Heparin sulphate injection 5000 IU when injected in the irrigation solution intraoperatively leads to decrease in postoperative inflammation in the early postoperative period. Therefore injection of heparin in the irrigation solution can be considered in cases where postoperative inflammation is expected. Conclusion: The group treated with heparin had significantly less inflammation in the early postoperative period and thereby there was a reduced necessity of anti-inflammatory agents. If, by adding heparin in the irrigating solution leads to decreased usage of postoperative steroids then it can emerge as a useful tool in preventing steroid related complications such as rise in postoperative intraocular pressure
Authors and Affiliations
Reshma Ramakrishnan, Nitesh Bhalla, Shrikant Deshpande, Minal Kanhere
Keywords
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