STUDY OF USING KOJIC ACID AS ANTICANCER IN DIFFERENT CONCENTRATION TO TREATMENT CANCERED RATS Rattus norvegicus BY CYCLOPHOSPHAMIDE
Journal Title: Scientific Journal of Medical Research - Year 2017, Vol 1, Issue 1
Abstract
Objective: This study was conduct to investigate effect of kojic acid to treatment ofcancered rate. Methods: Different concentration 0.5, 1, 2 mg/kg used as treatment through 30 days in some histological and functional criteria in cancered rats Rattus norvegicus by cyclophosphamide and the parameters that studied were WBC, PCV, HB , platelets , AST, ALT, and Bilirubin . Results: The result showed there is significant difference in blood parameters (WBC , platelets) at P≤ 0.01 and there is no significant difference in (HB , PCV) when compared with control group in addition T3, T4 , TSH levels showed no significant difference in all group of rats that treated with kojic acid when compared with control group at P≥ 0.01 also showed significant difference in ALT, AST, Bilirubin when compared with control group at P≤ 0.01 that lead to increase of ALT, AST, Bilirubin related to increase with kojic acid and then we showed significant change in the liver and kidney tissues in concentration 2 mg/kg of kojic acid when compared with control group and finally. Conclusion: We can consider the kojic acid is very good substance may be useful as antibiotic or antioxidant in some researches because it is very safe on the body .
Authors and Affiliations
Jasim A. Abdullah
Keywords
Related Articles
- EP ID EP204511
- DOI -
- Views 150
- Downloads 0
THE BETA-THALASSEMIA
The thalassemias are hereditary anemias caused by mutations that affect the synthesis of the globin, the protein component of the hemoglobin. Thalassemias produce massive public health problems in many parts of the world...
Virulence factors and antibiotic susceptibility patterns of Klebsiella pneumonia strains Histamine producing bacteria isolated from sputum
Objective: Histamine- producing bacteria(HPB) may be associated with much respiratory problem. Klebsiella pneumoniae is one of the most important pathogenic bacteria and is most frequently recovered from clinical specime...
Study Causes Of Repeated Abortion In Pregnant Women In Karbala City
Objective: The aim of the current study is to determine of causes of repeated abortion. Methods: During this study of causal agent of repeated abortion in pregnant women in Karbala city , 150 sample was taken from pregna...
Histopathological Study Of Toxicity Aflatoxin Of Treatment By Aqueous Extract Seed Pomgranate (Punica granulatum) In Male New Zealand White Rabbits (Oryctolacus cunnculus)
Objective: The current study focus on toxicity of aflatoxin of treatment by Aqueous extract seed pomgranate (Punica granulatum) in male New Zealand white Rabbits (Oryctolacus cunnculus) until we show the effect of three...
Prognostic significance of FOXP3+tumor-infiltrating lymphocytes in Basrah women of breast cancer
Objective: FOXP3 is a forkhead box transcription factor, a defining hall mark of Treg cells, and its functions as the master regulator in the development and function of regulatory T cell. Treg cells are sub set of T lym...