Study of Various Histopathological Patterns in Prostate Biopsy
Journal Title: International Journal of Current Research and Review - Year 2017, Vol 9, Issue 21
Abstract
Introduction: Diseases of prostate gland are important source of morbidity and mortality in male patients. The spectrum of diseases consists of inflammatory conditions, nodular hyperplasia, malignancy etc. The risk of diseases increases with age. Prostate biopsy is essentially a test which detects cancer and other benign conditions of the prostate in patients who have specific indications for it. Other modalities of diagnosis also have been developed, comprising of radiological modalities and prostatic biomarkers. However, biopsy with histopathological examination is the gold standard for the final diagnosis. Aims and Objective: To study various histopathological patterns in Transurethral resection of prostate(TURP) and needle biopsy of prostate, including benign prostatic hyperplasia(BPH), prostatitis (identifying type and grade of inflammation),incidental detection of carcinoma prostate and confirmation of diagnosis of clinically suspected carcinoma with application of modified Gleason system for grading. Materials and Methods: Total 100 cases of prostatic lesions including transurethral resection of prostate(TURP) and needle biopsy were evaluated in this study. The received specimens were fixed in 10% neutral buffered formalin and routine paraffin processing followed by hematoxyline and eosin staining was done. All the specimens were analysed with following parameters: type of specimen, age of patient, histopathological pattern and final diagnosis. Results: In total 100 cases of present study, the most common age group presenting prostatic lesions was 61-70 years. The youngest patient presenting with prostatic lesion was 45 years age, and oldest was of 85 years of age. In this, various histopathological patterns observed were- Benign prostatic hyperplasia (BPH)in 45%,benign prostatic hyperplasia (BPH)with co-existing chronic prostatitis in 10%, granulomatous prostatitis 1% (single case),acute prostatitis 3% and acute on chronic prostatitis 6%.Less frequent finding were benign prostatic hyperplasia (BPH)with basal cell hyperplasia 1%,benign prostatic hyperplasia (BPH)with squamous metaplasia 2%,benign prostatic hyperplasia (BPH)with clear cell changes 3% and some of biopsy show only stromal tissue with hyperplasia in 4%.We reported 7 cases of adenocarcinoma prostate with application of modified Gleason grading system. Conclusion: Benign lesions are more common than malignant lesions. Among the histological patterns of prostatic lesions, benign prostatic hyperplasia (BPH)is predominant type. It is necessary to study all prostate biopsy [Transurethral resection of prostate(TURP)and needle] in order to identify premalignant lesions, proliferative activity, and grade of inflammation. Histopathological diagnosis and grading plays a definitive role in the management of prostatic cancer.
Authors and Affiliations
Dr. Mital Yadav
Keywords
Related Articles
- EP ID EP607553
- DOI -
- Views 99
- Downloads 0
Study on Blood Donation Among Medical Students of Udaipur City, Rajasthan
Background: This study has been carried out to know the knowledge, attitude and behavior about blood donation among medical college students of Udaipur city. Human blood is an essential element of life and it cannot be s...
A Study on Infrastructural Facilities for Differently Abled in Banks
Introduction: Differently abled is a term applied to all persons with disabilities including those having long term physical, intellectual impairment, mental impairments etc. Person with disability often struggle with th...
A Review on Biochemical Aspects of Schizophrenia
Schizophrenia is a severe disorder affecting the brain. Defective neurotransmitters and altered neurotransmission system maybe one of the various causes for this psychiatric disease. There are several hypotheses explaini...
Study of Breast Lesions with Special Reference to Rare Malignant Epithelial Tumors in a Tertiary Care Hospital with Brief Review of Litreature
Background and Aim: Lesions of the breast vary from completely benign Fibroadenomas to Invasive Carcinomas No Special Type (NST) and rare malignant lesions. Breast cancer is ranked as number one cancer among females in I...
Pleomorphic Adenoma of Breast, Unusual in its Location
Aim: Pleomorphic adenoma (PA) is a common benign mixed tumor of salivary gland. It rarely involves the breast and due to limited yield of tissue samples on fine needle aspiration and core biopsies, it poses a diagnostic...