Study of Various Liver Enzymes in Patients with Organophosphorous Poisoning
Journal Title: Walawalkar International Medical Journal - Year 2018, Vol 5, Issue 2
Abstract
Organophosphate (OP) pesticides are used widely for agriculture, vector control, and domestic purposes. Organophosphate poisoning (OPP) is most commonly results from exposure to these pesticides either accidentally or consumed for suicidal purpose. OPP is one of the most common causes of poisoning worldwide including India especially among the farmers. The patients with the OPP are classified according to the Peradeniya Organophosphorous Poisoning (POP) Scale. POP scale is a scoring system based on clinical features. In OPP there is decrease in serum cholinesterase level. So serum cholinesterase level is mostly used as a supportive laboratory investigation for the confirmation of diagnosis of OPP and is severity. But this laboratory investigation is not available in all laboratories especially in rural areas where OPP is very common. So we have investigated serum liver enzymes along with serum cholinesterase level in OPP and tried to find out the relation between liver enzymes with OPP and serum cholinesterase. Aims and Objectives: 1) Estimation of the level of following parameters before any treatment - Serum liver enzymes like alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphates (ALP) , 2) Comparison of the above parameters in the controls with the OPP cases. 3) Comparison of liver enzymes with serum acetyl cholinesterase level in OPP. Material and methods: This study will be carried in the department of the Biochemistry in the Dr. Shankarrao Chavan Government Medical College, Nanded (MS). Inclusion criteria: 1) Patients with definite history of ingestion of organ phosphate compound poisoning within twenty-four hours of admission. 2) Patients with presence of characteristic clinical signs and symptoms of organophosphate compound poisoning. A valid written consent was taken from 60 patients admitted in the Hospital. These patients were divided into two groups as- Group-I is control with 30 patients and Group-II has 30 patients with OPP. After obtaining history, clinical examination, 5ml of blood sample is taken in plain bulb by single prick for laboratory investigations before any treatment. Serum acetyl cholinesterase and liver enzymes were estimated in the above patients. Data will be represented as Mean ± S.D. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 11.5. Conclusions: Serum liver enzymes like alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) increases in all cases of OPP. These enzymes had shown inverse relationship with the levels of serum acetyl cholinesterase. Further level of these enzymes significantly increases in cases where serum cholinesterase activity falls below 50% of normal value which is suggestive of severe OPP. Hence these liver enzymes can be used in OPP instead of acetylcholinesterase where laboratory facilities are limited and they not only help in the diagnosis of OPP but also suggest severity of OPP.
Authors and Affiliations
Ganesh. Manoorkar
Keywords
Related Articles
- EP ID EP534982
- DOI -
- Views 73
- Downloads 0
Incultating Core Competencies in Physiology in a Playful Learning Environment
Background: Medical Council of India emphasizes the need for self directed active learning among undergraduate students. Traditional lectures alone are poor means of transferring/acquiring information less effective at s...
Multidisciplinary Management of Sebaceous Gland Carcinoma of Upper Eyelid with Regional Lymph Node Metastasis
Sebaceous gland carcinoma (SGC) of ocular adnexa is a highly malignant, multifocal in origin seen in elderly. SGCs are known to have highly virulent course of progression with more tendency to metastasize locally and sys...
Study of Lipid Profile, Oxidative Stress, And Antioxidant Status, In Type-2 Diabetes Mellitus
Background: Diabetes mellitus is regarded as a metabolic syndrome, a collection of disorders that have hyperglycemia as the hallmark. Type-2 Diabetes mellitus (Type-2 DM) is now epidemic in many countries undergoing mode...
Negative Impact of Troublesome Peer Interactions and Authoritarian Parenting Style on Academic Performance of a 15 year Old Boy
Adolescence is a period of great turbulence characterized by cognitive, emotional, social and physical changes. Family environment and role of peers is extremely crucial in the development of an adolescent. Presenting he...
Current Status of Medical Research in India- Where are we?
Medical research, particularly clinical research adds enormous value in furthering science and adding quality to medical practice. Evidence based medicine is a new buzz world of Modern medicine. Medical colleges are expe...