Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 2
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder showing an increasing trend with an increase in complications such as diabetic retinopathy (DR), which can cause blindness. Most patients do not notice vision loss early; hence, it is beneficial to have dysfunction of the retina identified. Patients with T2DM and DR have shown abnormalities in visually evoked potentials (VEPs). Objectives: To investigate whether VEPs can be used to detect early changes related to T2DM and DR. Materials and Methods: A total of 111 patients, of both sexes and aged 40-70 years, were studied as three groups of 37 each, who were, respectively, patients with T2DM, patients with DR, and normal subjects. For all the groups, VEP recording was done using Medicaid Neurostim EP machine, and retinal examination was done using direct ophthalmoscopy. The latency and amplitude of P100 in VEP of both eyes were, respectively, analyzed using analysis of variance and post-hoc test. Results: Our results showed significantly prolonged P100 latencies of VEPs in T2DM patients and DR patients when compared to controls. However, there was no a significant difference observed in the P100 amplitudes of VEPs in T2DM patients and DR patients when compared to controls. Conclusion: The present study has highlighted the importance of VEP as a valuable non-invasive test to detect early neuronal changes in T2DM patients and can be recommended for monitoring early effects of diabetes on visual function.
Authors and Affiliations
Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass
Keywords
Related Articles
- EP ID EP288256
- DOI 10.5455/njppp.2017.7.0824424082016
- Views 63
- Downloads 0
The clinical skills of emergency medical staff confronting trauma
Background: Today, the accidents and catastrophes causing trauma are one of the fundamental health needs of industrial world, and also a prevalent cause of mortality, especially in Iran. Thus, pre-hospital and emergency...
S100 can be used as a tumor marker in canine mammary tumors
Background: S100 protein has been localized in different normal and tumorous tissues. Furthermore, its use in tumor localization and identification has already been established. Aims and Objectives: The aim of this study...
Impact of bioaerosol exposure on respiratory health of saw-mill workers
Background: Occupational environments with organic dust and bioaerosols pose danger to the respiratory health of the personnel of such environments. Respiratory health of the workers of saw-mills in relation to airborne...
Assessment of knowledge, attitude, and practice of pharmacovigilance among clinicians and postgraduate students in a teaching medical institution - A questionnaire study
Background: Spontaneous voluntary adverse drug reaction (ADR) reporting is the backbone for the successful functioning of the Pharmacovigilance Programme of India. Aims and Objectives: These study objectives were to asse...
Normative data of peak expiratory flow rate in healthy school children of Ghaziabad city—a pilot study
Background: Age, sex, weight, and height are the main factors that affect peak expiratory flow rate (PEFR). Various authors have shown that geographical, climatic, anthropometric, nutritional, and socioeconomic co...