Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 2
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder showing an increasing trend with an increase in complications such as diabetic retinopathy (DR), which can cause blindness. Most patients do not notice vision loss early; hence, it is beneficial to have dysfunction of the retina identified. Patients with T2DM and DR have shown abnormalities in visually evoked potentials (VEPs). Objectives: To investigate whether VEPs can be used to detect early changes related to T2DM and DR. Materials and Methods: A total of 111 patients, of both sexes and aged 40-70 years, were studied as three groups of 37 each, who were, respectively, patients with T2DM, patients with DR, and normal subjects. For all the groups, VEP recording was done using Medicaid Neurostim EP machine, and retinal examination was done using direct ophthalmoscopy. The latency and amplitude of P100 in VEP of both eyes were, respectively, analyzed using analysis of variance and post-hoc test. Results: Our results showed significantly prolonged P100 latencies of VEPs in T2DM patients and DR patients when compared to controls. However, there was no a significant difference observed in the P100 amplitudes of VEPs in T2DM patients and DR patients when compared to controls. Conclusion: The present study has highlighted the importance of VEP as a valuable non-invasive test to detect early neuronal changes in T2DM patients and can be recommended for monitoring early effects of diabetes on visual function.
Authors and Affiliations
Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass
Keywords
Related Articles
- EP ID EP288256
- DOI 10.5455/njppp.2017.7.0824424082016
- Views 68
- Downloads 0
Study of brainstem auditory evoked potentials in normal healthy persons
Background: Auditory evoked potentials (AEPs) are very small electrical voltage potentials signal generated by a sound through the auditory pathway. Age and gender influence on the brainstem AEPs(BAEPs) deserve keen appr...
Effect of yoga on indices of cardiovascular system in Maharashtrian adolescent girls
Background: Yogic exercises are scientifically observable physiological and biochemical activities. Certain yogasanas decrease the sympathetic tone, rate pressure product (RPP), and double product (DoP) and improv...
Pulmonary function in petrol pump workers in Anand district
Background: Petrol pump workers are exposed to the petrol fumes exhibit a number of effects on the respiratory functions. Health effects of occupational exposure to gasoline and air pollution from vehicular s...
Assessing body composition by bioelectric impedance analysis and dual-energy X-ray absorptiometry in physically active normal and overweight Indian males
Background: To improve body composition measurement methods for physically active healthy individuals, validation with of bioelectric impedance analysis (BIA) with using dual-energy X-ray absorptiometry (DXA) on basis of...
Learning styles and approaches toward pharmacology curriculum among medical undergraduates
Background: Learning styles (LSs) and learning approaches (LAs) of each medical student vary to a great extent. If LSs and LAs of the students are known, the teaching-learning programs can be developed in an appropriate...