Study of Vitamin D status in patients with dilated cardiomyopathy at a teaching hospital in North India
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 4
Abstract
Background: Vitamin D plays a vital role in maintaining adequate serum calcium and phosphate levels for bone mineralization and optimal skeletal health. Recent literature, however, have indicated a much broader role of vitamin D than simply the regulation of calcium metabolism as vitamin D receptors (VDRs) are found in a variety of cells and tissue. Aim: Aim of our work was to evaluate presence of hypovitaminosis D in patients with dilated cardiomyopathy and to study any correlation of echocardiographic parameters with vitamin D deficiency. Material and method: An observational cross-sectional hospital based study, 26 patients diagnosed to have dilated cardiomyopathy and 26 age, gender and body mass index matched controls who were patients of other medical illnesses were included into the study between January- 2012 to December 2014 at Era's Lucknow Medical College and Hospital, Lucknow according to World Health Organization criteria. Results: There were no differences in age gender, body mass index and sun exposure within the groups. Prevalence of diabetes mellitus and hypertension was similar in the two groups. Biochemical parameters were not significantly different in all study participants except that patients with DCMP had low calcium levels than the control group. Conclusion: Patients with DCMP had lower vitamin D levels than controls and vitamin D deficiency had significant correlation with cardiac function. Therefore, screening for vitamin D deficiency along with prompt treatment is recommended in patients with DCMP. Future studies are needed to address the precise role of vitamin D deficiency in causation of DCMP.
Authors and Affiliations
Aman Mor, Ritu Karoli, Sachin Khanduri, Vaibhav Shukla
Keywords
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