STUDY OF WITHANIA COAGULANS EXTRACTS FOR ANTIDIABETIC ACTIVITY IN EXPERIMENTAL RAT MODELS
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 6
Abstract
The present study defines the systematic evaluation and the role of active constituents by their glycemic potential of extracts of Withania coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. Experimental diabetes was induced in 30 albino rats with intraperitoneal injection of streptozotocin (50 mg/kg). The rats were divided into five groups receiving the following treatments orally for 4 weeks: Vehicle, glipizide (2.5 mg/kg), WCDF extract (1000 mg/kg), WCDF extract (1000 mg/kg) plus glipizide (1 mg/kg) and WCDF extract (1000 mg/kg) plus glipizide (2.5 mg/kg). Fasting and postprandial blood glucose levels were measured every week for 4 weeks. The 4‑week treatment with WCDF extract significantly reversed hyperglycemia in streptozotocin‑induced diabetes that was comparable to glipizide. When combined with glipizide (2.5 mg/kg), WCDF extract produced a synergistic antihyperglycemic effect. The present study, besides confirming hypoglycemic and antidiabetic activities of W. coagulans, helps in identifying the role of trace minerals like Mg & Ca responsible for antidiabetic potential of this potent indigenous shrub.
Authors and Affiliations
S. D. Haseeb Jafferi
Keywords
Related Articles
- EP ID EP649325
- DOI -
- Views 155
- Downloads 0
DRUG DOSES IN PEDIATRIC PRACTICE – AN AYURVEDIC LITERARY REVIEW
Equilibrium of Dosha’s and freedom from all diseases is called health .For this purpose of health, Acharya‟s have made Ayurveda. Ayurveda is one of the most ancient medical science in the world. It conceives and describe...
A REVIEW OF AN AYURVEDIC MANAGEMENT OF VANDHYTVA W.S.R. TO CERVICAL FECTOR
Introduction: Vandhyatva (Infertility) has been long standing problem since ancient period. Infertility is increasing now-a-days. Many herbal and herbo-mineral formulations are mentioned as a treatment of Infertility in...
DIETARY REFORMS FOR HEALTHY PREGNANCY AS PER ANCIENT TEXTS
In the Ayurvedic classics it has been beautifully explained with a very good example that in order to achieve good quality grain four factors i.e. Beeja, Ambu, Kshetra and Kala is important likewise to attain healthy chi...
ANALYTICAL STABILITY INDICATING UPLC ASSAY AND VALIDATION USING C18 COLUMN FOR FLUOROMETHOLONE IN PARENTERAL DOSAGE FORM
A pecific, precise, accurate and stability indicating UPLC method is validated for estimation of Fluorometholone in parenteral inhaler dosage form. The method employed, with C18 column (250 ×4.6 mm id)—ACE Generix in gra...
e-MEDICINE PROVIDES 24 HOURS WEEKLY NONSTOP SERVICE TO THE BEST OF MANKIND
e-medicine is serving to the human by following 24 hours weekly without any fail for best and prompt medical help. Just as the printing press democratized information, the medicalized smartphone will democratize health c...