STUDY OF WITHANIA COAGULANS EXTRACTS FOR ANTIDIABETIC ACTIVITY IN EXPERIMENTAL RAT MODELS
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 6
Abstract
The present study defines the systematic evaluation and the role of active constituents by their glycemic potential of extracts of Withania coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. Experimental diabetes was induced in 30 albino rats with intraperitoneal injection of streptozotocin (50 mg/kg). The rats were divided into five groups receiving the following treatments orally for 4 weeks: Vehicle, glipizide (2.5 mg/kg), WCDF extract (1000 mg/kg), WCDF extract (1000 mg/kg) plus glipizide (1 mg/kg) and WCDF extract (1000 mg/kg) plus glipizide (2.5 mg/kg). Fasting and postprandial blood glucose levels were measured every week for 4 weeks. The 4‑week treatment with WCDF extract significantly reversed hyperglycemia in streptozotocin‑induced diabetes that was comparable to glipizide. When combined with glipizide (2.5 mg/kg), WCDF extract produced a synergistic antihyperglycemic effect. The present study, besides confirming hypoglycemic and antidiabetic activities of W. coagulans, helps in identifying the role of trace minerals like Mg & Ca responsible for antidiabetic potential of this potent indigenous shrub.
Authors and Affiliations
S. D. Haseeb Jafferi
Keywords
Related Articles
- EP ID EP649325
- DOI -
- Views 157
- Downloads 0
SPECTROSCOPIC CHARACTERIZATION FOR ADSORPTION PROCESSES OF CADMIUM IONS (cd+2) ONTO ZEOLITE-A TREATED BY COLD PLASMA
In this manuscript, we have studies the spectroscopic characterization (FTIR-ATR, X-ray diffraction and SEM-EDS analysis) for adsorption processes of cadmium ions (Cd+2) onto zeolite-A treated by cold plasma and effect o...
NUTRITIONAL CONSULTATION ON PREGNANT WOMEN: EFFECT ON INTAKE, WEIGHT GAIN, MID-UPPER ARM CIRCUMFERENCE AND HEMOGLOBIN
Maternal mortality problems in pregnant and gave birth women are a major problem in developing countries. The study aimed to identify the influence of nutrition consultation of a balanced diet on macronutrient, weight ga...
HYPERSPLENISM AND LIVER CIRRHOSIS
Objective: To determine the frequency of cases with hypersplenism presenting with liver cirrhosis. Methodology: This was a cross sectional study conducted at Sheikh Zayed Hospital, Rahim Yar Khan. In this study the diagn...
BEWARE LEAD IS STILL INTRUDING OUR DAILY LIFE
Lead (Pb) is a toxic metal that has been known for ages and has also been used widely and wildly in plumbing, leaded petrol, as antiknock, rubber industry, paints, and lead batteries. We aimed at investigating several ch...
ROLE OF VAMANA KARMA AND NIMBADI CHURNA WITH PATOLADI KWATHA AS ANUPANA IN THE MANAGEMENT OF EKA KUSHTA W.S.R. PLAQUE PSORIASIS
In today‟s world everyone sees what you appear to be. Appearance is nothing but the skin. Skin diseases are affecting the mankind since time immortal. Skin is a mirror that reflects external and internal pathology, and i...