STUDY ON CLINICAL PROFILE, OUTCOME AND HLA-B27 ASSOCIATION IN JUVENILE IDIOPATHIC ARTHRITIS- ENTHESITIS RELATED ARTHRITIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 77
Abstract
BACKGROUND Juvenile Idiopathic Arthritis (JIA) is defined as arthritis in one or more joints persisting for 6 weeks or more, which begins before the 16th birthday and has no other known cause. In contrast to the western literature only 11% - 16% of patients with JIA have ERA, In India it is probably the commonest subtype of JIA seen clinically. Data on outcome of ERA patients from India are scarce. This study was taken up to assess the clinical profile, outcome, incidence of Juvenile ankylosing spondylitis, HLA-B27 association of Juvenile idiopathic arthritis- enthesitis related arthritis. MATERIALS AND METHODS History, clinical examination, radiological imaging like musculoskeletal x-rays, musculoskeletal USG, CT, MRI of sacroiliac joints, biochemical investigations and immunological investigations (HLA-B27) were done for all patients. Material and Selection- Inpatients and outpatients of Institute of Rheumatology, Rajiv Gandhi Govt. General Hospital and Madras Medical College, Chennai. The study period was Jan. 2015 to Jan. 2017. The study was undertaken after obtaining approval from the Institutional Ethical Committee. An informed consent was obtained from all patients and parents. RESULTS The median age at the time of the study of the 50 patients with ERA was 16 years (range 9 - 33 years) and the median duration of disease was 5 years (3 months - 18 years); 49 patients were male and one patient was female. Median age at disease onset was 14 (8 - 15) years; 17 (34%) of the patients were HLA-B27 positive. Three (6%) patients were in remission at the time of the study; 15 patients (30%) had joints with limitation of motion; 18 (36%) patients had decreased anterior lumbar flexion movement by modified Schober’s method. CONCLUSION Axial inflammation was common in HLA-B27 positive patients. Functional limitations were observed in one-third of the EnthesitisRelated Arthritis patients. JADI is a useful tool to measure articular and extra-articular damage in ERA; 70% of JIA-ERA patients had enthesitis (Two-third of the patients had enthesitis).
Authors and Affiliations
Mayilsamy Saravanan, Chinnadurai Saranya, Mantharam Vignesh, Vengudusamy Sivakumar, Annamalai Sowndhariya, Seetharaman Mythili
Keywords
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- EP ID EP267588
- DOI 10.14260/Jemds/2017/1196
- Views 79
- Downloads 0
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