Study on Clinical-Radiological Profile of Patients with Sero-Negative And Sero-Positive Rheumatoid Arthritis According to the Eular Criteria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Aims: Study On Clinical-Radiological Profile Of Patients With Sero-Negative And Sero-Positive Rheumatoid Arthritis According to the EULAR Criteria. Methods: This is a analytical observational study where we proposed to analyse the clinical features in respect to the work disability and functional impairment as well as the radiological progression /damage in two groups of seronegative and the seropositive subjects Results: This study was conducted to correlate the clinical and radiological changes between Seronegative and Seropositive rheumatoid arthritis diagnosed according to the EULAR criteria.Maximum patients were between 61 to 70 age group in the Seronegative group forming 38.07%, whereas in the Seropositive subjects it is 61 to 70 years forming 33.93% and also 51 to 60 years forming 25% of the total age group.Females formed the major group constituting 69.6 % as compared to 30.35% of males.EULAR scores were greater in the Seropositive subjects ( 7.35±1.048) as compared to Seronegative subjects ( 6.59±0.696)Pain scale was higher in the Seropositive subjects ( 65.32 ±16.95 with P<0.0001)as compared to the Seronegative subjects ( 36.11 ±21.70 ) Wellness scale was greater in the Seronegative subjects assessed by the examiner ( 62.97 ±21.34) as compared to the Seropositive subjects which was 40.42 ±18.59. Health assessment questionnaire (HAQ-DI) scores were greater in the Seropositive subjects 92.07 ±0.491 ) as compared to the Seronegative subgroups which is 0.959 ±0.451.Disease activity index 28 ( DAS28) score was higher in Seropositive subgroup ( 5.05±0.812 ) as compared to to Seronegative subgroup which was 3.18 ±0.715. Conclusions: In our study maximum patients belonged to the 60 to 70 age group that were diagnosed as RA, who were further classified as seronegative and seropositive subgroups.The seropositive subgroup showed more clinical disease and disability progression as compared to the seronegative subgroup when compared with the various disease activity indices and scoring systems for Rheumatoid arthritis at the given point of time.Similarly, radiological progression or erosions was seen to be more in the seropositive subgroup where maximum patients were grouped under the grade 5 class of Larsen’s scoring system, whereas for the seronegative subgroup, maximum patients had progression only upto class 3 of larsen’s indicating a more pronounced radiological damage in SP subgroup at the given point of time. Our study observations point to a greater clinical and radiological rheumatoid disease activity in cases which are seropositive as compared to the seronegative counterparts in the study when different appropriate scoring systems and scales were properly applied .
Authors and Affiliations
Dr. Pratik Patil, Dr. Mahendra Wawhal, Dr. Ashwini Karale, Dr. Rohan Hegde
Keywords
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