Study on Effect of Levothyroxine Replacement Therapy on Some Biochemical Markers of Renal Function in Hypothyroid Patients in Tertiary Care Centre of Kumaon Region
Journal Title: International Journal of Research and Review - Year 2018, Vol 5, Issue 10
Abstract
Introduction- Thyroid hormones are essential for energy metabolism, growth and development of various body organs including kidneys. The literature concerning the association between renal function changes with the severity of hypothyroidism and the effects of levothyroxine replacement therapy is unclear. Aims and objectives- This study was therefore conducted with aim to assess the derangements in biomarkers of renal function in hypothyroid patients as well as to observe the effects of thyroxine treatment in these subjects. Materials and methods- 215 subjects were enrolled in the study. 135 newly diagnosed cases of hypothyroidism were divided into 2 groups; subclinical hypothyroids (GII; n=75) and overt hypothyroid (GIII; n=60). The results were compared with 80 euthyroid controls (GI; n=80). 83 selected subjects; 38 of subclinical hypothyroidism and 45 overt hypothyroid cases were followed up with repeat of renal and thyroid function tests after 3 months of thyroxine replacement therapy (L-T4 therapy). Serum sample for TSH, T3 and T4 was analysed on autoanalyser e411 of Roche diagnostics. Serum urea, creatinine and uric acid estimation was done on cobas 501c of Roche diagnostics. Results- Mean levels of serum creatinine and uric acids were raised in overt hypothyroid & subclinical cases as compared to controls. The levels of serum creatinine (p<0.001) & uric acid (p<0.05) were significantly elevated in OH cases when compared with SH cases. No significant change was observed in serum urea levels in SCH and OH cases in comparison to euthyroid controls. There was a significant reduction in levels of Serum creatinine, uric acid levels in SCH and OH cases after 3 months of levothyroxine replacement therapy, while there was no change in serum urea levels. A significant positive correlation of creatinine (p<0.0242) and uric acid (p<0.0281) with TSH and negative correlation of urea and T4 was observed in hypothyroid group as whole before therapy. Conclusions - This study concludes that there is deterioration in renal function with progression of hypothyroidism and the derangements are reversible with restoration of thyroid hormone levels by levothyroxine replacement therapy. Thus, clinicians can advise the renal function tests while screening and treating hypothyroid patients.
Authors and Affiliations
Seema Gupta
Keywords
Related Articles
- EP ID EP482405
- DOI -
- Views 50
- Downloads 0
Ancient Schwannoma Involving the Superficial Peroneal Nerve: A Case Report and Review of the Literature
Introduction: Schwannomas are benign, encapsulated, slow-Growing and usually solitary tumors originating from Schwann cells of the peripheral nerve sheath. Histological findings are these seen as in conventional schwanno...
Effect of Innovation Strategies on Competitive Advantage in Public Secondary Schools in West Pokot Sub County, West Pokot County
The purpose of the study was to investigate the effect of innovation strategies on competitive advantage in public secondary schools in West Pokot sub County of West Pokot County. The analysis was focused on the responde...
Yield Stability and Agronomic Performance of Rain Fed Upland Rice Genotypes by Using GGE Bi-Plot and AMMI in North West Ethiopia
The study was conducted at Fogera, Pawe, Assosa, Gondar and Mai-tsebri in Ethiopia during 2016-2017 with the objective of identifying high yielding, major disease resistance and stable rice varieties for rain fed upland...
Prevalence of Thyroid Dysfunction in Pregnancy and Its Outcome: The Indian Scenario
Thyroid gland is the most important endocrinal gland in the human’s body. It plays the important role in maintaining the metabolic rate and body’s homeostasis mechanism. [12] But however some physiological changes occur...
Effects of Tomato Extract (Lycopersicon Esculentum) on Carbimazole-Induced Alterations in Kidney of Albino Rats
Acute Kidney Injury has a very high mortality and morbidity despite advances in clinical treatment. The health benefits of tomato extract on kidney injury has not been extensively studied. This research investigated the...