STUDY ON EFFECTS OF CARBAMAZEPINE AND PHENYTOIN ON DEVELOPMENT OF CHICK EMBRYO
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2016, Vol 5, Issue 6
Abstract
The knowledge about the Teratogenic drugs is crucial while prescribing medications to the pregnant women. Treating epileptic pregnant women is always challenge as most of antiepileptic drugs are potent teratogens and the increase of seizures and alterations in drug clearance further complicates the medication advice to pregnant women with seizure disorder. The present experimental study used fresh fertilized white leg horn chicken eggs to know the effects of carbamazepine and phenytoin administration during critical period of organogenesis i.e. on 5th day of incubation. Control eggs were injected distilled water and the study group were injected by various doses of drug concentration in distilled water. Chick embryos were collected on 19th day of incubation, first gross malformation were observed and recorded. Liver tissue has been collected from chick embryos for histological study. High mortality rate observed in chick embryos treated with higher dose of drug concentration. Hepatic damage, loss of normal architecture of liver, vacuolations, dilated central vein, inflammatory infiltration with significant portal inflammation observed. The mortality rate with more number of gross malformations recorded in phenytoin administered group than carbamazepine.
Authors and Affiliations
Anil Kumar Reddy| Department of Anatomy, ANIIMS, Port Blair, Andaman and Nicobar Islands, India, Fulzele R R| Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India, UjwalGajbe| Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India, Kondam Ambareesha| Assistant Professor, Department of Physiology, MNR Medical College& Hospital, Sangareddy, Telangana, India- 502001
Measurement of Procalcitonin in acute exacerbation of COPD and its correlation to Spirometric Indices
Background: rational prescription of antibiotics in acute exacerbation of COPD (AECOPD) requires predictive markers. Acute phase reactants are capable of demonstrating the inflammation; however, they cannot be employed...
Formulation and evaluation pf Phospholipid complex of Green Tea Polyphenol
OBJECTIVE: Phospholipid complexes are formulated to improve absorption, bioavailability and stability of herbal product. There are many herbal extracts having excellent in-vitro activity but less in-vivo activity becau...
COMPARATIVE IMMUNOMODULATOR ACTIVITY OF LEAVES AND BARK OF ALBIZIA LEBBECK (LINN.) BENTH
Adaptability is probably the most distinct characteristics of life which may be defined as sum of all non specific response of the body to any demands made upon it; fundamentally it was a physiological response; primary...
Assessment of Home Based Newborn Care provided by ASHA worker in a Rural Block of Haryana
Objective: The first month of life, the post-natal period, for the mother and the newborn is the most critical time in the life. Based on these facts Government of India took an initiative, Home Based Post Natal Care (...
Formulation and characterization of mouth dissolving mucoadhesive buccal film of Zolmitriptan
Fast dissolving buccal film drug delivery system is an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms....