Study on Electrophysiological Changes of Peripheral Nerves in Type 2 Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Diabetic peripheral neuropathy is a common and disabling complication of diabetic mellitus. In diabetic neuropathy sensory, motor and autonomic functions are affected in varying degrees with sensory function predominating. Once neuropathy developed it cannot be reversed nor can it be stopped with any modality of treatment. Electrodiagnostic studies used in proper setting are a valuable tool for the evaluation of diabetic neuropathy as they are sensitive, specific, reproducible and easily standardized. In the present study 40 patients were subjected to study status of peripheral nerves in type 2 diabetic patients, by studying the conduction velocity (MNCV, SNCV), distal Latency (DL), nerve action potential (SNAP, CMAP). All the cases were divided into 2 groups based on normal and abnormal DNS score. Sex, BMI matched 30 numbers of healthy adults of both sexes were included in the control group. All the three groups were subjected to NCS and compared. Out of 40 cases of type 2 diabetes 15(37.5%) were with symptoms of peripheral neuropathy. The majority of cases were in the fifth decade (45%) with mean age of 52.42±7.39, having predominance of male (66.67%) in cases with symptoms of neuropathy. Out of 15 cases with clinical neuropathy 14 (93.33%) were having abnormal NCS where as in cases without clinical neuropathy 14(56%) out of 25 were with abnormal NCS. Our study showed abnormal motor and sensory nerve conduction parameters. A statistically significant decrease in the mean values of CMAP, SNAP, MNCV and SNCV with prolonged distal latency is observed more in lower limbs than in upper limbs. In the category of motor nerves Common peroneal nerve is the most affected where as Sural nerve the most affected in sensory series. Sensory nerve conduction is seen to be more impaired than motor nerve conduction. Screening for neuropathy must be recommended in clinical practice for early diagnosis of neuropathies and their management
Authors and Affiliations
Dr. Umakant Satapathy
Keywords
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