Study on Elevated Maternal Serum Alpha-Fetoprotein in Second Trimester and Pregnancy Outcome
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 7
Abstract
This study was a prospective observational study sponsored by DBT (Department of Biotechnology), New Delhi. It was carried out in Gauhati Medical College and Hospital during the period 2014-15 with a total of 202 women whose maternal serum alpha-fetoprotein (MSAFP) was measured between 16 and 20 weeks of gestation. The objective of the study was to determine whether elevated MSAFP level between 16 and 20 weeks of gestation is associated with increased risk of adverse pregnancy outcome including preterm birth, preeclampsia/ eclampsia, SGA, Stillbirth/Neonatal death. MSAFP level was determined by using an immunometric immunoassay technique. Women with MSAFP level ≥ 2.5MoM were defined as elevated MSAFP. Results showed women with elevated MSAFP were significantly more likely to have subsequent adverse pregnancy outcome (70%) compared to women with MSAFP < 2.5 MoM (18.6%) (p<0.0001) with a relative risk of 3.76 (95% confidence interval 2.5 -5.5).It was thus concluded from the study that there is a strong association between elevated MSAFP in the second trimester and a subsequent adverse pregnancy outcome including preterm birth, preeclampsia/eclampsia, SGA (Small for gestational age) and Stillbirth/ neonatal death. Keywords: maternal serum alpha-fetoprotein (MSAFP), preterm birth, preeclampsia, Stillbirth
Authors and Affiliations
Ashish Kumar Bhattacharjee, Mandeep Bayan, Gitanjali Deka
Keywords
Related Articles
- EP ID EP373450
- DOI -
- Views 50
- Downloads 0
Yuvika- A Report of Life Skills Training Workshop for Adolescent Girls in Rural Maharashtra
Adolescence is a period of biological, cognitive and social transition. Key aspects of adolescents’ lives include sexual and reproductive health, education and nutrition. Physical and sexual abuse, the lack of autonomy a...
Prevalence of Mood Variances in Patients with Osteoarthritis of Knee
Abstract: Chronic debilitating medical problems do have definite impact over the state of mind, physical activity and adjustment with the daily needs. Though all have good/favorable adaptability, the threshold varies in...
Correlation between Iron Deficiency Anemia and Febrile Seizure
Abstract: Febrile seizure is a common cause of seizure occurring in 3-5% children under 5 years of age. Iron is important for neurological functions and development of brain. Iron deficiency anemia can be a risk factor f...
A Study of Bacterial Vaginosis with special reference to Gardnerella vaginalis
In Bacterial Vaginosis, the normal lactobacilli dominated flora is replaced by a mixed predominantly anaerobic flora. There is an increase in the obligatory facultative anaerobes like Gardnerella vag...
Relationship between Lipid Profile and Left Ventricular Mass in Obese Adolescents
Childhood obesity is associated with an increased risk of death due to cardiomyopathy and atherosclerosis in adulthood. Hyperlipidemia, hypertension, obesity, diabetes mellitus, smoking, lack of exercise, and family hist...