STUDY ON FRESH LEAF AQUEOUS EXTRACT OF FLACOURTIA INDICA FOR HEPATOPROTECTIVE, ANTI-ANEMIC AND HYPOGLYCEMIC ABILITIES IN CCL4 INDUCED HEPATOTOXICITY IN ALBINO WISTAR RATS
Journal Title: UNKNOWN - Year 2019, Vol 4, Issue 1
Abstract
Hepatic injury and its associated conditions have been reportedly shown to be managed through herbal remedies. In this study, investigation of the fresh leaf aqueous extract of Flacourtia indica (of the family of Salicaceae) as hypoglycemic, anti-anemic and hepatoprotective agent in albino wistar rats induced CCl4 hepatotocxicity was done. Fifteen rats of either sex, weighing 175-295g, divided into five groups (I-V) of three rats each, were used. Group-I is negative control, II-positive control and III –V test groups. Groups II-V were induced 200mg/Kg/bodyweight CCl4, for 3-days, for hepatic injury and anemia. Groups III-V were respectively treated orally with 400, 600 and 800 mg/Kg/bodyweight of fresh leaf aqueous extracts (FLAE) of Flacourtia indica, for 7-days. Activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, concentrations of bilirubin, albumin, total protein, blood glucose and packed cell volume (PCV) and hemoglobin were assayed. Results after induction showed significant (p˂0.05) decrease in heamoglobin and PCV, significant (p˂0.05) increase in the liver function enzymes and blood glucose compared with results of liver function enzyme and blood glucose having significant (p˂0.05) decrease, and significant (p˂0.05) increase of PCV and hemoglobin after treatment with FLAE of Flacourtia indica. Body weight of rats induced CCl4 was found to increase with FLAE of Flacourtia indica treatment. It may be concluded that the potentials exhibited by FLAE of Flacourtia indica to manage hyperglycaemia, hepatic injury and anemia induced by CCl4 are associated with its antioxidant activity and the presence of phytochemicals, minerals and nutrients value. Keywords: Anti-anemic, Flacourtia indica, hepatoprotective, hepato-function, hypoglycemia, Toxicity.
Authors and Affiliations
Idoko A
Keywords
Related Articles
- EP ID EP490364
- DOI -
- Views 67
- Downloads 0
EXAMINING THE IMPACT OF ACCESS TO HEALTHCARE INFORMATION IN PROVIDING SERVICE IN HOSPITAL LEVEL OF HORMOZGAN PROVINCE
Examining the impact of access to healthcare information in providing service in hospital level was performed in Hormozgan province. The study is applied in objective respect. The statistical population of this study inc...
PREVALENCE AND POTENTIAL RISK FACTORS OF HEPATITIS B VIRUS IN A SAMPLE OF CHILDREN IN TWO SELECTED AREAS IN YEMEN
The global epidemic of hepatitis B is a significant public health problem. The endemicity of HBV infection used to be believed high in Yemen. Data for the prevalence of HBsAg among children in rural and urban areas in Ye...
PREVALENCE OF PSEUDOMONAS AERUGINOSA (P. AERUGINOSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN
Pseudomonas aeruginosa is clinically significant and opportunistic pathogen that causes infections in hospitalized patients. Antibiotic resistance is a major concern in clinical practice. The ongoing emergence of resista...
PREVALENCE OF CYTOMEGALOVIRUS IGG ANTIBODIES, POTENTIAL RISK FACTORS AND AWARENESS OF CONGENITAL CYTOMEGALOVIRUS AMONG FEMALE DOCTORS
Female staff in children-Mother care hospitals may run an increased risk of cytomegalovirus (CMV) contact infection leading to a congenital CMV feto-pathy during pregnancy. Also, because of limited treatment options for...
GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS
Gas chromatography-Mass spectrometry (GC-MS) is an analytical method that combines the features of gas-liquid chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC...