Study on Hemorheological Properties of Erythrocytes in Asymptomatic Hyperuricemia Rat Model
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 10
Abstract
Background: Hyperuricemia causes gout syndrome, which can manifest as hemorheological damage. However, hemorheological properties have not been well characterized in asymptomatic conditions. Aims: The present study was aimed to investigate the hemorheological changes in rats with asymptomatic hyperuricemia. Methods and Materials: The rat model was established by intraperitoneal injection of 250 mg/(kg·d) oxonate acid for 8 weeks. In one group of rats, 70 mg/(kg·d) allopurinol was also administrated for the latter 4 weeks. Control rats were administered CMCNa solution and water. Results: Hyperuricemic rats had higher blood viscosity than control rats did. Moreover, their erythrocytes had reduced deformation index, orientation index, surface charges, and osmotic fragility. Treatment with allopurinol decreased the blood uric acid amounts and improved the hemorheological parameters. Conclusions: Our study suggests that there is deterioration in the hemorheology of hyperuricemic rats and that allopurinol can play a protective role on the deterioration. Therefore, hemorheology can be used as a diagnostic tool in asymptomatic hyperuricemia.
Authors and Affiliations
Kuihua Li| Hemorheology Center, Chengde Medical College, Chengde, Hebei Province, China, Xiaobo Tong| Hemorheology Center, Chengde Medical College, Chengde, Hebei Province, China, Corresponding e-mail: nobuo@faculty.chiba-u.jp; tongxiaobo2012@163.com, Weijuan Yao| Hemorheology Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, Xifu Wang| Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, Atsushi Suzuki| Department of Cardiology, Tokyo Women`s Medical University, Tokyo, Japan, Nobuo Suzuki| Non-proft Organization, Chiba Researchers Network for Health Care Promotion, Chiba, Japan
Keywords
Related Articles
- EP ID EP12461
- DOI -
- Views 336
- Downloads 14
Preconcentration and analysis of cannabinoid compounds (THC-9, CBN, CBD) in urine samples by IL-ISFME/D-µ-SPE/HPLC-DAD
In this work we applied a recently developed ionic liquid assisted in-situ solvent formation microextraction coupled with magnetic nano-particle based dispersive micro-solid phase extraction following by HPLC diode arra...
A COMPARATIVE STUDY OF ARTERIAL STIFFNESS INDICES BETWEEN SMOKERS & NON SMOKERS
Arterial stiffening is recognized as a critical precursor of cardiovascular disease. Smoking is one of the modifiable risk factor for cardiovascular disease. Lifestyle modification is clinical efficacious therapeutic i...
GARENOXACIN IN SKIN & SKIN STRUCTURE INFECTIONS COMPLICATED BY BEAR BITE
Animal bites have always been a common problem to humans. The incidence of resistant organisms is also increasing in the community. Garenoxacin a novel oral des-fluoroquinolone with potent antimicrobial activity agains...
PHYTOCHEMICAL SCREENING AND ACUTE TOXICITY STUDY OF ETHANOLIC EXTRACT OF ALPINIA GALANGA IN RODENTS
Introduction: Alpinia galanga is an important ingredient in various herbal formulations has reached extensive acceptability as therapeutic agents for several diseases. The investigation of authentic analytical methods,...
Acute Chikungunya Fever Presenting as Migratory Polyarthritis
The tropical arthritogenic chikungunya virus has become an increasingly medical and economic burden in affected areas as it can result in long term disabilities. Thus, the current challenge for physicians in epidemic ar...