Study on Hemorheological Properties of Erythrocytes in Asymptomatic Hyperuricemia Rat Model
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 10
Abstract
Background: Hyperuricemia causes gout syndrome, which can manifest as hemorheological damage. However, hemorheological properties have not been well characterized in asymptomatic conditions. Aims: The present study was aimed to investigate the hemorheological changes in rats with asymptomatic hyperuricemia. Methods and Materials: The rat model was established by intraperitoneal injection of 250 mg/(kg·d) oxonate acid for 8 weeks. In one group of rats, 70 mg/(kg·d) allopurinol was also administrated for the latter 4 weeks. Control rats were administered CMCNa solution and water. Results: Hyperuricemic rats had higher blood viscosity than control rats did. Moreover, their erythrocytes had reduced deformation index, orientation index, surface charges, and osmotic fragility. Treatment with allopurinol decreased the blood uric acid amounts and improved the hemorheological parameters. Conclusions: Our study suggests that there is deterioration in the hemorheology of hyperuricemic rats and that allopurinol can play a protective role on the deterioration. Therefore, hemorheology can be used as a diagnostic tool in asymptomatic hyperuricemia.
Authors and Affiliations
Kuihua Li| Hemorheology Center, Chengde Medical College, Chengde, Hebei Province, China, Xiaobo Tong| Hemorheology Center, Chengde Medical College, Chengde, Hebei Province, China, Corresponding e-mail: nobuo@faculty.chiba-u.jp; tongxiaobo2012@163.com, Weijuan Yao| Hemorheology Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, Xifu Wang| Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, Atsushi Suzuki| Department of Cardiology, Tokyo Women`s Medical University, Tokyo, Japan, Nobuo Suzuki| Non-proft Organization, Chiba Researchers Network for Health Care Promotion, Chiba, Japan
Keywords
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