Study on hypogonadism in male with Type 2 Diabetes Mellitus
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 2
Abstract
Type 2 diabetes is associated with subnormal free testosterone concentrations in conjunction with inappropriately low LH and FSH concentrations in at least 25% of men suffering from this disease. In this study, we have evaluated the prevalence of hypogonadism in young non obese people with T2DM in our population and explored whether testosterone therapy would be able to reduce insulin resistance. Two hundred and seven male with Type 2 diabetes with age between 30 years and 50 years, on usual therapy with stable dose of drugs for last 3 months with HbA1C less than 9% and BMI less than 30kg/m2 were selected and assessed for total serum testosterone. Twelve patients with serum total testosterone levels <350 ng/dl were treated with injection testosterone treatment. LH, FSH, HOMA-IR at baseline was done before giving testosterone. Serum total testosterone levels were re-assessed at 3 and 6 months in this group. After 6 months, glycemic status, BMI, waist circumference, HOMA-IR and lipid profile were re-evaluated. Prevalence of hypogonadism (serum total Testosterone <350ng/dl) was found to be 8.7% which was not increasing either with age or duration of diabetes. Prevalence of hypogonadism showed significant positive relation with BMI but not with HbA1c. After testosterone replacement, improvement was noticed in BMI, HbA1c, HOMA-IR and HDL level. Non obese young male with type 2 diabetes with good glycemic control and without complications may not have higher risk of developing hypogonadism compared to those reported in western literature. However, chance of erectile dysfunction is much higher which is probably due to other independent risk factors for ED.
Authors and Affiliations
Saumik Datta, Pradip Mukhopadhyay, Sujoy Ghosh, Subhankar Chowdhury
Keywords
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