Study on locoregional response with combined modality using conventional dose radiation therapy and concurrent single agent cispatin chemotherapy in locally advanced hypopharyngeal and laryngeal squamous cell carcinomas
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 4
Abstract
Background: In the Indian situation, as of now, there can only be two ways of controlling malignancies. One is by way of primary prevention and the other being managing the advanced disease. Thus, comparatively newer modalities of concurrent chemoradiation particularly with cisplatinum are producing high locoregional control. Aim: To describe the loco-regional response with combined modality treatment using conventional dose radiation therapy and concurrent single agent cisplatin chemotherapy in locally advanced hypopharyngeal and laryngeal squamous cell carcinomas, to describe the toxicity profile and feasibility of treatment regimen with combined modality chemo-radiation therapy, to describe the success with organ preservation in locally advanced hypopharyngeal and laryngeal cancers using combined modality chemo- radiation therapy. Materials and methods: Total number of patients available for analysis was 26. All the patients were assessed for immediate response and for acute local and systemic toxicities. The end points of the study included. The initial tumor response - immediately on completion of treatment and at 6 weeks, Acute local and systemic toxicity due to concurrent chemotherapy and radiation therapy, Organ preservation. Results: Concurrent chemoradiation using conventional dose radiation therapy (6600 CGy) and single agent CDDP given on days 1, 22, 43 as studied in this cross sectional study achieves significant local control rates and organ preservation goals. The toxicities seen in this combined modality regimens appeared to be tolerable. Study showed with statistical significance, that the T stage and stage of a disease affects response at local and regional node sites respectively. Conclusion: Concurrent chemoradiation using conventional dose radiation therapy (6600 CGy) and single agent CDDP given on days 1, 22, 43 as studied in this cross sectional study achieves significant local control rates and organ preservation goals.
Authors and Affiliations
Sivagnanam Balaji, N Sudhahar
Keywords
Related Articles
- EP ID EP414125
- DOI -
- Views 130
- Downloads 0
A study of phacoemulsification cataract surgery preference over Small Incision Cataract Surgery in rural eye center of Bodhan, Nizamabad District
Cataract is a major cause of decreased vision in elderly aged population. In rural areas till last decade small incision cataract surgery with IOL implantation is the only surgical option for treating cataracts. In recen...
Serum β HCG as a predictor and potent marker for pregnancy induced hypertension
Background: Hypertensive disorders are also responsible for perinatal mortality and morbidity. Pre-eclampsia is a risk factor for stillbirth, IUGR, LBW, Preterm delivery, Respiratory distress syndrome, and admission in t...
Comparative study of diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) with ultrasonography in choledocolithiasis with post endoscopic retrograde cholangio-pancreatography (ERCP) correlation
Background: Choledocolithiasis may be classified into primary and secondary forms. Primary choledocolithiasis denotes de novo formation of stones, often made of calcium bilirubinate within the ducts. Materials and Method...
Uterine Cavity Assessment and Endometrial Hormonal Receptors in Women with Peri and Post-Menopausal Bleeding
Background: Abnormal uterine bleeding (AUB) is any heavy or unusual bleeding from the uterus (through your vagina). It can occur at any time during your monthly cycle, including during your normal menstrual period. Aim:...
Comparative clinical study of attenuation of cardiovascular responses to laryngoscopy intubation diltiazem, lignocaine and combination of diltiazem and lignocaine
Background: In contributing the patient care, Anaesthesia and endotracheal intubation have become a core part of anaesthesiologists. Via nose or mouth, the trans-laryngeal placement of endotracheal tube into the trachea...