Study on Lupus Pattern of Dyslipidemia in Systemic Lupus Erythematosus
Journal Title: Scholars International Journal of Biochemistry - Year 2019, Vol 2, Issue 2
Abstract
This study aimed to find a lupus pattern of dyslipidemia in Systemic Lupus Erythematosus (SLE).Thirty SLE cases and thirty age matched controls are included in this study. Fasting venous blood was collected and base line investigations, lipid profile, apoB and apoA1 estimations were done. Statistical analysis was performed using SPSS package 19. The groups were compared using Student’s t test. Analysis of lipid profile across the cases and controls reveals that the mean triglycerides, the mean Low Density Lipoproteins and the mean Very Low Density Lipoproteins were higher among cases with statistical significance and the mean total cholesterol and the mean High Density Lipoproteins seen more in controls with statistically insignificant p value. Apo B values were high and low APOA1 values seen in SLE compared to controls. Higher Apo B/Apo A1 ratio in SLE cases. This ratio implies that the number of small dense LDL particles are the most atherogenic particles that are easily oxidize and promote inflammation and growth of plaques. This elevated lipid profile and apolipoprotein levels in SLE patients throws light on the fact that SLE patients are at increased risk for Coronary Artery Disease.
Authors and Affiliations
Rajalakshmi Kumarasamy, Bhuvaneswari Rajendran
Keywords
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