Study on microstructural changes in white matter fibers of patients with post stroke depression based on automated fiber quantification

Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 10

Abstract

[Objective] To explore the microstructural changes in white matter (WM) fibers of patients with post-stroke depression (PSD) by using automated fiber quantification (AFQ) and the relationship between changes in fibers and the Hamilton depression scale (HAMD). [Methods] The HAMD and MRI data were collected from stroke patients with a single anterior circulation infarction at 1-month follow-up. AFQ was used to extract the main fibers and calculate the fractional anisotropy (FA) of each node in each fiber. The difference of node FA in each fiber between groups and correlations between altered node FA and HAMD were then evaluated. [Results] Data were collected from 8 patients with PSD and 18 patients without PSD (non-PSD). Compared with that in non-PSD, the node FA in the callosum, left inferior longitudinal fasciculus, and uncinate fasciculus were significantly decreased in patients with PSD (P<0.05). The altered node FA values in the corpus callosum forceps minor (r=-0.418, P=0.047) and left uncinate fasciculus (r=-0.467, P=0.029) were negatively related to HAMD in patients with PSD. [Conclusions] AFQ can precisely measure the segmental microstructural damage of nerve fiber bundles in patients with PSD, of which segmental microstructural damage of the corpus callosum forceps and hook tracts is associated with the severity of depression.

Authors and Affiliations

Qiuhong LU, Yanlan HUANG, Jie LIU, Miao WANG, Zhijian LIANG, Shunzu. LU

Keywords

Related Articles

Progress in clinical treatment of low-grade gliomas

low-grade glioma (LGG) is a slow-growing primary brain tumor originating from glial cells. The overall prognosis of LGG is good but incurable. The vast majority of LGG will have relapses, and some even progress to high-g...

Rapid progressive dementia and involuntary movement caused by vitamin B12 deficiency: a case report

A 41-year-old male was presented with rapidly progression memory impairment for 2 months and episodic limb shaking for 2 weeks as the main manifestations. Physical examination showed verbal disadvantage with decreased me...

Efficacy analysis of endoscopic endonasal and craniotomy surgery in the treatment of craniopharyngioma Based on QST Classification

[Objective] This study aims to explore the efficacy and complication rates of the transcranial approach (TCA) and extended endoscopic endonasal approach (EEEA) for the treatment of craniopharyngiomas based on the QST cla...

A metabolome-wide case-control study of social anxiety disorder in patients with schizophrenia

[Objective] To explore the metabolic markers of social anxiety disorder in schizophrenia patients with social anxiety disorder through metabolomic sequencing analysis. [Methods] From December 2022 to December 2023, a cas...

Analysis of phenotype conversion and its influencing factors in patients with first-episode depression: Based on a 7-year follow-up

[Objective] To understand phenotype conversion in patients with first-episode depression over a 7-year period, to explore the longitudinal disease characteristics and functional outcomes of transitions and non-transition...

Download PDF file
  • EP ID EP759180
  • DOI 10.3969/j.issn.1002-0152.2024.10.003
  • Views 48
  • Downloads 0

How To Cite

Qiuhong LU, Yanlan HUANG, Jie LIU, Miao WANG, Zhijian LIANG, Shunzu. LU (2024). Study on microstructural changes in white matter fibers of patients with post stroke depression based on automated fiber quantification. Chinese Journal of Nervous and Mental Diseases, 50(10), -. https://europub.co.uk/articles/-A-759180