Study on multi-target mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen Persicae (Taoren) on adhesion intestinal obstruction based on network pharmacology
Journal Title: Traditional Medicine Research - Year 2019, Vol 4, Issue 4
Abstract
Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang) (RERR) and Semen Persicae (Taoren) (SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.
Authors and Affiliations
Yin-Zi Yue, Li Zeng, Xiao-Peng Wang, Yang Zong, Shuai Yan
Keywords
Related Articles
- EP ID EP45311
- DOI 10.12032/TMR20190526121
- Views 240
- Downloads 0
Research on Xijiao Dihuang Decoction suppressing platelet apoptosis in immune-mediated aplastic anemia based on mitochondrial mediated pathway
The aplastic anemia mice model was established in this study. BALB/c mice shall be treated with whole body irradiation with 60 Co-γradiation (5.5Gy, 1.1Gy/min × 5 min). then within 4 h, DBA/2 mice were injected lymphocyt...
Treatment of diabetic foot ulcer with medicinal leech therapy and honey curcumin dressing: a case report
Highlights Wound healing impairment and ulcers in the foot, with pain and disability, are common complications of diabetes. The present case report shows the effectiveness of leech therapy in combination with honey an...
The present treatment and mechanism progress of arsenic trioxide in hematological malignancies
This paper reviewed the development history of arsenic trioxide (ATO), and summarized its mechanisms and clinical application in the treatment of hematologic malignancies. ATO can induce tumor cell apoptosis, tumor cell...
Study on an innovative natural drug for Alzheimer's disease reported as a sham
The number of patients with dementia is estimated to be as high as 24 million and is predicted to double every 20 years, i.e., by 2040, leading to a tremendous financial disease burden [1]. Therefore, we urgently need to...
Marine natural products with anti-inflammation effects
The ocean possesses a complex setting with high pressure, high salinity, oligotrophy, low temperature and weak illumination conditions. To survive and evolve in such harsh surroundings, marine organisms metabolize a seri...