Study on multi-target mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen Persicae (Taoren) on adhesion intestinal obstruction based on network pharmacology

Journal Title: Traditional Medicine Research - Year 2019, Vol 4, Issue 4

Abstract

Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang) (RERR) and Semen Persicae (Taoren) (SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.

Authors and Affiliations

Yin-Zi Yue, Li Zeng, Xiao-Peng Wang, Yang Zong, Shuai Yan

Keywords

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  • EP ID EP45311
  • DOI 10.12032/TMR20190526121
  • Views 237
  • Downloads 0

How To Cite

Yin-Zi Yue, Li Zeng, Xiao-Peng Wang, Yang Zong, Shuai Yan (2019). Study on multi-target mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen Persicae (Taoren) on adhesion intestinal obstruction based on network pharmacology. Traditional Medicine Research, 4(4), -. https://europub.co.uk/articles/-A-45311