Study on phototherapeutic keratotomy for bacterial corneal lesions in rabbit
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 5
Abstract
AIM: To study the effect of phototherapeutic keratectomy(PTK)on rabbit bacterial corneal ulcer model and explore the clinical potential of this method. <p>METHODS: Totally 48 eyes from all the 24 New Zealand rabbits were inoculated with <i>Staphylococcus aureus</i> and bacterial corneal ulcer model was established successfully. At 1d after inoculation, 48 eyes were given levofloxacin eye drops when corneal ulcer was confirmed. Then slit lamp inspection and optical coherence tomography(OCT)were performed to measure the central corneal ulcer depth. All the rabbits right eyes were treated with PTK, as an observation group, left eyes were not treated as a control group. The eye section were observed by slit lamp and central thickness of corneal ulcer was measured by OCT at 3 and 7d after this operation. Rabbits were sacrificed and the cornea was removed for pathological section 7d later. <p>RESULTS: The corneal ulcers in both groups had a tendency to heal, showing a decrease in ulcer area and smoothness of the surface. There was no significant difference in the depth of corneal ulcer between the observation group and the control group before PTK(<i>t</i>=0.706, <i>P</i>=0.484). The difference between the two groups of eyes at 3 and 7d after PTK was obviously(<i>P</i><0.05). <p>CONCLUSION: PTK can effectively cure rabbit <i>Staphylococcus aureus</i> corneal ulcer and promote ulcer wound healing, which may be used for clinical treatment of patients with bacterial corneal lesions.
Authors and Affiliations
Xin Zhou
Keywords
Related Articles
- EP ID EP580414
- DOI 10.3980/j.issn.1672-5123.2018.5.08
- Views 141
- Downloads 0
Effect on enophthalmos between different edge point repairment after orbital wall fracture repair surgery
AIM: To investigate the importance between several edge points repair through enophthalmos study after orbital wall fracture repair surgery. <p>METHODS: The date of 23 eyes of 23 cases with medial-inferior orbital wall f...
Effect of microRNA-155 on the pathogenesis of primary open angle glaucoma
microRNA is specifically expressed in ocular tissues and plays a unique role in ocular tissues. microRNA-155 regulates a variety of signaling pathways, affects the expression of the corresponding protein, then leads to t...
Effects of sodium hyaluronate on ocular inflammatory response and dry eye after phacoemulsification combined with IOL implantation for cataract
AIM: To investigate the effect of sodium hyaluronate eye drops on ocular inflammatory response and dry eye after phacoemulsification combined with intraocular lenses(IOL)implantation for age-related cataract. <p>METHODS:...
Correlation between extracellular MMP-9 polymorphism and genetic susceptibility of PACG in a Han Chinese population
AIM: To analyze the association of extracellular matrix metalloprotease 9(MMP-9)single nucleotide polymorphism(SNP)with genetic susceptibility of primary angle-closure glaucoma(PACG)in a Han Chinese population. <p>METHOD...
Effects of Shuangdan Mingmu capsule on the expressions of VEGF in the retina of diabetic rat models
AIM: To study the effects of Shuangdan Mingmu capsule on the expressions of vascular endothelial growth factor-a(VEGF-a), VEGF-b, VEGF-c in the retina of a diabetic rat model. <p>METHODS: Forty male SD rats were divided...