Study on the association between Hyperuricemia and Albuminuria in patients of type 2 Diabetes Mellitus
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 12
Abstract
Introduction: Type 2 diabetes mellitus is associated with a high rate of complications related to cardiovascular disease and diabetic nephropathy, retinopathy, and neuropathy. Type 2diabetes patients with increased urinary albumin excretion suffer increased morbidity and mortality as compared to normoalbumiuric patients. In clinical studies, serum uric acid concentration has been found to be associated with diabetic nephropathy. On the other hand, we also know that albuminuria is the main marker of diabetic nephropathy independent of hypertension. Aim: This hospital-based observational (cross-sectional) study aimed to evaluate the relationship of serum uric acid level & urinary albumin creatinine Ratio (ACR) in patients of T2DM. Material and methods: The study group comprised of 100 patients of type 2 diabetes mellitus of age between 40 to 80 years. Age, body weight, height, body mass index (BMI),serum uric acid, urinary albumin to creatinine ratio (ACR), fasting blood glucose (FBG), glycated haemoglobin (HbA1c), lipid profile, serum creatinine were recorded for each patient. Patients were diagnosed to have diabetes mellitus on the basis of American Diabetes Association (ADA) criteria. Results: Albuminuria was found to be significantly associated with hyperuricemia. Serum uric acid as found to be a significant factor which could predict only 40.2% (R2 = 0.4028) variation in albumin creatinine ratio. Conclusion: This study showed that the serum uric acid concentration was significantly and with greater probability associated with albuminuria in patients with type 2 diabetes mellitus.
Authors and Affiliations
Deepali Kaushal, N. S Neki, Sat Pal Aloona, Rohit Bhardwaj Bhoj Raj Sharma, K. Shankar, Manpreet Singh
Keywords
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- EP ID EP548968
- DOI 10.22192/ijcrms.2018.04.12.012
- Views 248
- Downloads 0
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