Study on the change of retinal thickness and choroidal thickness and correlative factors for macular edema after Ranibizumab injection
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 5
Abstract
AIM: To evaluate the change of retinal thickness and choroidal thickness in patients with diabetic macular edema or retinal vein occlusion-macular edema after intravitreal Ranibizumab injection using spectral domain-optical coherence tomography(SD-OCT), and to identify determinants for the change of different types of macular edema. <p>METHODS: Patients were recruited from March 2016 to July 2017 diagnosed with diabetic macular edema or retinal vein occlusion-macular edema. Subfoveal choroidal thickness(SFCT)and central retinal thickness(CRT)of all eyes were measured by SD-OCT preoperatively and at 1, 3, 6mo after operation. The change of retinal thickness and choroidal thickness after intravitreal ranibizumab injection for macular edema caused by different diseases were evaluated. Moreover, the potential determinants were studied about the change of retinal thickness and choroidal thickness. <p>RESULTS: Thirty-six eyes of 36 patents with macular edema were treated with intravitreal ranibizumab injection. After the intravitreal ranibizumab injection, the CRT and SFCT decreased, when compared with the CRT and SFCT preoperative. There was a significant difference in the change of CRT and SFCT in different time points of following-up(<i>F</i><sub>CRT</sub>=40.876, <i>P</i><sub>CRT</sub><0.001; <i>F</i><sub>SFCT</sub>=46.319, <i>P</i><sub>SFCT</sub><0.001). In diabetic macular edema group, the change of SFCT was associated with the preoperative SFCT, and the change of CRT was correlated with preoperative CRT and the fast blood glucose level. In retinal vein occlusion-macular edema group, the change of SFCT was associated with the preoperative SFCT, the change of CRT was associated with preoperative CRT, the obstructive positions and the onset time of disease. <p>CONCLUSION: Reduction of choroidal thickness and retinal thickness in macular edema caused by different diseases can be detected with SD-OCT after intravitreal injections of ranibizumab. The reduction of choroidal thickness was correlated with the preoperative choroidal thickness. In diabetic macular edema eyes, the reduction of retinal thickness was correlated with preoperative CRT and the fast blood glucose level. Whereas, in retinal vein occlusion-macular edema eyes, the reduction of retinal thickness was correlated with the preoperative CRT, the obstructive positions and the onset time.
Authors and Affiliations
Jie - Hui Xu
Keywords
Related Articles
- EP ID EP581423
- DOI 10.3980/j.issn.1672-5123.2018.5.27
- Views 93
- Downloads 0
Ahmed glaucoma valve implantation treatment of traumatic angle recession glaucoma
AIM: To study the influence of Ahmed glaucoma valve implantation on eyesight, intraocular pressure and corneal endothelial cell density of patients with traumatic angle recession glaucoma. <p>METHODS: Totally 33 cases(35...
Effect of calcium dobesilate combined with panretinal photocoagulation on severe non-proliferative diabetic retinopathy patients
AIM: To study the effect of calcium dobesilate combined with panretinal photocoagulation on severe non-proliferative diabetic retinopathy patients(NPDR). <p>METHODS:A total of 92 patients(184 eyes)with severe NPDR were c...
Correlation between symptoms and sign of drug users with dry eye
AIM: To investigate the correlation between symptoms and sign of drug users with dry eye. <p>METHODS: Eighty-seven patients(87 eyes)with dry eye syndrome who were abstained from a compulsory rehabilitation center in Yang...
Risk factors associated with the severity of diabetic retinopathy in Qingdao
AIM:To investigate and analyse the prevalence and risk factors associated with diabetic retinopathy severity in Qingdao.<p>METHODS: This survey consisted of the 2 following parts: 2859 community residents aged >60 years...
Research progress on anti-scarring drugs after glaucoma filtration surgery
Glaucoma filtration surgery is currently the preferred method for patients in whom anti-glaucoma medication and laser treatment can not control intraocular pressure, and its postoperative filtering bleb scar formation is...