Study on the In-vitro Release Kinetics of Olmesartan-loaded Optimized Solid Lipid Nanoparticles
Journal Title: International Journal of Nano Research - Year 2018, Vol 0, Issue 1
Abstract
Drugs with low aqueous solubility not only give low oral bioavailability but provide high inter-and intra-subject variability. Solid lipid nanoparticles (SLN) have gained much interest as potential drug carriers for lipophilic drugs. Olmesartan medoxomil has very poor aqueous solubility and belongs to Class II drugs under Biopharmaceutical Classification Systems. The objective of the present study is to determine release kinetics of Olmesartan medoxomil- loaded solid lipid nanoparticles. Olmesartan medoxomil-loaded solid lipid nanoparticles was prepared by hot homogenization and ultra-sonication method. Particle size, polydispersity index, shape and surface morphology were used to characterize the formulations. The degree of encapsulation of the drug in the formulations was estimated by determining the drug entrapment efficiency. The in-vitro drug release from the formulations was studied using dialysis membrane. The drug release kinetics of the formulation was analyzed using different kinetics models. The results show that the formulations are spherical in shape with smooth surface and possess particle size range of 122.8-135.0 nm, polydispersity index range of 0.208-0.239. The entrapment efficiency was in range of 94.5-96.8%. Fourier transform infrared spectroscopy (FTIR) and differential scanning colorimetry (DSC) test results are considered to be satisfactory. The in-vitro drug release study demonstrated that drugloaded formulations possessed controlled drug release characteristics. The kinetics release results suggest the possible mechanism of action for the drug release might be diffusion of the drug from the formulation. Zero-order drug release kinetics model out of the models investigated, best fitted the in-vitro release data.
Authors and Affiliations
Ndidiamaka Hannah Okorie
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