Study on transfusion-related acute lung injury caused by HLA-Ⅱ antibody
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 10
Abstract
Objective To explore the risk factors of transfusion-related acute lung injury (TRALI). Methods The clinical symptoms, signs, imaging examinations, and laboratory test results of two patients with TRALI after blood transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) genotyping of the patient and HLA antibodies typing of the plasma donors were performed. Results The clinical manifestations and laboratory parameters of two patients were consistent with those of TRALI after blood transfusion. After timely clinical respiratory support treatment, all patients were improved. Blood donors produced high titers of HLA-Ⅱ antibodies after pregnancy, including antibodies that specifically recognize the patient′s HLA antigen. Conclusion Two patients developed TRALI after platelet transfusion from a female blood donor, which was caused by HLA-Ⅱ antibodies.
Authors and Affiliations
Yu ZOU, Mao ZHENG, Xin JI, Xiuyun LIAO, Tianhua JIANG, Jue WANG
Keywords
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- EP ID EP738658
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.10.007
- Views 43
- Downloads 0
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