Study on treatment outcome and risk factors of multidrug-resistant pulmonary tuberculosis patients in Shanghai
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 3
Abstract
ObjectiveTo describe the characteristics of treatment outcomes of multidrug-resistant tuberculosis ï¼MDR-TBï¼ patients enrolled in second-line treatment in Shanghai from 2017 to 2018ï¼ and to analyze the influencing factors of treatment outcomes.MethodsTotally 182 MDR-TB patients were analyzed by using data collected from the China tuberculosis management information systemï¼ the hospital's electronic medical record information systemï¼ whole genome sequencing results and a questionnaire surveyï¼ and logistic regression analysis was used to analyze the factors affecting the success of treatment.ResultsIn 182 MDR-TB patientsï¼ the success rate of treatment was 65.4%ï¼ the loss to follow-up rate was 8.2%ï¼ the mortality rate was 4.9%ï¼ the unassessable rate was 13.7%ï¼ and the drug withdrawal rate was 7.7%. The factors affecting the success of treatment in MDR-TB patients included age ï¼35â years oldï¼ OR=5.28ï¼ 95%CIï¼ 1.58â17.59ï¼ P=0.007ï¼ 55â years oldï¼ OR=16.30ï¼ 95%CIï¼ 4.36â60.92ï¼ P<0.001ï¼ and compliance to medication ï¼OR=0.55ï¼ 95%CIï¼ 0.42â0.72ï¼ P<0.001ï¼.ConclusionThe treatment success rate of MDR-TB patients in Shanghai from 2017 to 2018 is significantly higher than the average level in China. Older patients and patients with less compliant are at higher risk of adverse treatment outcomes.
Authors and Affiliations
NING Chenxi,ZHANG Shiqi,WU Zheyuan,CHEN Jing,ZHANG Zurong,SHEN Xin,YUAN Zheng'an,
Keywords
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