Study on Variation of Exon 8 and 16 of Goat MLPH Gene
Journal Title: Journal of Medical Science And clinical Research - Year 2013, Vol 1, Issue 2
Abstract
The variation of exon 8 and 16 of MLPH gene in different Chinese indigenous goat breeds with different color and locations was investigated in order to understand its genetic diversity. The mutation sites g.G9109A and g.G9125A in exon 8 and g.G18951A and g.A18955C in exon 16 were found. The g.G18951A and g.A18955C in exon 16 were in complete linkage disequilibrium and formed two haplotypes, GA and AC. Meanwhile the complete linkage mutation sites in exon 16 were in second structure domain of MLPH protain, which might affect its function. Leizhou black goat, Jining grey goat and Liaoning Cashmere goat were in Hardy-Wenberg disequilibrium at g.G18951A and g.A18955C in exon 16 except for Nanjiang Brown goat. In exon 16, Jining grey goat and Liaoning Cashmere goat had a closer relationship while Leizhou black goat was the farthest. The location of goat breeds affected the gene flow
Authors and Affiliations
Liying ZHANG
Keywords
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